04-07 July, 2016
Goethe University Hospital
Campus Niederrad, Building 22
Theodor-Stern-Kai 7
D-60590 Frankfurt am Main
GERMANY

 

Programme

 

Monday, July 4th

 

15.00-20.00 Arrival and registration
Foyer building 22
17.50-18.00 Opening and welcome
Ivan Dikic
Lecture hall 22-1
18.00-18.40 Keynote lecture

Aaron Ciechanover
Technion, IL     
Monoubiquitination as a novel proteasomal degradation signal: mechanistic and biomedical implications

KL1
18.45-19.25

Keynote lecture
Helen Saibil
University of London, UK      

Microscopy studies of protein misfolding and aggregation in cellular models of amyloid disease   
KL2
19.30-20.10

Keynote lecture
Ulrich Hartl
Max Planck Institute of Biochemistry, DE

Molecular chaperones in protein folding and quality control
KL3
20.15 Welcome reception
Foyer building 22
   
Tuesday, July 5th
Session I Ubiquitination and autophagy networks
Chairs: Anne Bertolotti and Volker Dötsch
Lecture hall 22-1
09.00-09.25 Brenda Schulman
St. Jude Children's Research Hospital, US
Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C
L1
09.30-09.45 Christian Behrends
Goethe University Frankfurt, DE
Ubiquitin in host-pathogen encounters
L2
09.50-10.15

Wade Harper
Harvard Medical School, USA
Digitizing ubiquitin signaling for mitophagy

L3
10.20-10.35 Koraljka Husnjak

Goethe University Frankfurt, Germany
Identification of novel players in linear ubiquitination

L4
10.40-11.05

Simone Fulda                                                              
Goethe University Frankfurt, Germany
Therapeutic targeting of selective autophagy in cancer

L5
11.10-11.40

Coffee break

Foyer building 22
11.40-12.05

Herbert W. Virgin
Washington University School of Medicine, USA
Regulation of tissue inflammation by autophagy genes through multiple mechanisms

L6
12.10-12.35

Zvulun Elazar
Weizmann Institute, Israel
Autophagy balances proteasomal degradation

L7
12.40-12.55

Evgenij Fiskin
Goethe University Frankfurt, Germany
Bacterial ligase SopA targets host TRIM ligases to control Salmonella infection

L8
13.00-13.25

Felix Randow
LMB Cambridge, UK

How cells defend their cytosol against bacterial invasion
L9
13.30-15.00

Lunch and poster session I (posters P001-P057)

Foyers and seminar room, building 22
   
Session II

Protein translation, folding and aggregation
Chairs: Blanche Schwappach and Christian Behrends

Lecture hall 22-1
15.00-15.25

Judith Frydman
Stanford University, USA
Chaperone mediated protein folding and misfolding in the eukaryotic cytosol

L10
15.30-15.55

Bernd Bukau
DKFZ & ZMBH, Heidelberg, Germany

Mechanisms of chaperone mediated protein disaggregation
L11
16.00-16.25

Anne Bertolotti
LMB Cambridge, UK 

Correcting protein quality control failure as a strategy against neurodegenerative diseases
L12
16.30-16.55

Claudio Joazeiro
ZMBH, Heidelberg, Germany

The E3 Ligase Listerin/Ltn1 links ribosome-associated quality control (RQC) and neurodegeneration
L13
17.00-17.30 Coffee break
Foyer building 22
17.30-17.55

Stefan Müller
Goethe University Frankfurt, Germany
Shaping protein assemblies by dynamic SUMOylation

L14
18.00-18.15

Martin Vabulas
Goethe University Frankfurt, Germany

Recognition of apoproteins
L15
18.20-18.45

Christian Behl
Johannes Gutenberg University Mainz, Germany

BAG3 and RAB3GAP1/2 as modulators of selective macroautophagy and proteostasis
L16
18.50-19.15

Jörg Höhfeld
Rheinische Friedrich Wilhelms University Bonn, Germany

Chaperone-assisted degradation – from mechanisms to pathology
L17
19.20-19.35

Yifat Merbl
Weizmann Institute, Israel

GARDing the secretory pathway via Golgi quality control
L18
  Free evening
Wednesday, July 6th
Session III

Membrane and organelle quality control 

Chairs: Judith Frydman and Jörg Höhfeld
Lecture hall 22-1
09.00-09.25

Ramanujan Hegde
LMB Cambridge, UK

Quality control of proteins mislocalized in the cytosol
L19
09.30-09.55

Blanche Schwappach
Georg August University Göttingen, Germany

The Trc40 pathway in proteostasis
L20
10.00-10.15

Heinz D. Osiewacz
Goethe University Frankfurt, Germany

Autophagy in mitochondrial quality control and organismal aging
L21
10.20-10.45

Tassula Proikas-Cezanne
Eberhard Karls University Tübingen, Germany

WIPI proteins scaffold autophagy signal control
L22
10.50-11.05

Christian Pohl
Goethe University Frankfurt, Germany
Autophagy and organismal stress

L23
11.10-11.30 Coffee break
Foyer building 22
11.30-11.55

Michael Thumm
Georg August University Göttingen, Germany

Structure and molecular function of PtdIns3P-binding b-propellers in autophagy
L24
12.00-12.25

Thomas Sommer
Max-Delbrück-Center for Molecular Medicine, Germany

Function of specific Ubiquitin Ligase complexes in Protein Quality Control
L25
12.30-12.55

Gerhard Hummer
Max Planck Institute of Biophysics, Germany

Molecular modeling of autophagy associated processes
L26
13.00- 13.25

Tom Rapoport
Harvard Medical School, USA

Mechanism of ERAD elucidated with purified components
L27
13.30-15.00 Lunch and poster session II (posters P058-P113)
Foyers and seminar room, building 22
Session IV

Quality control of signaling and nuclear events
Chairs: Tassula Proikas-Cezanne and Christian Behl

Lecture hall 22-1
15.00-15.25

Carl-Henrik Heldin
Ludwig Institute for Cancer Research Uppsala, Sweden

Signaling via TGFb receptors – a possible target in tumor therapy
L28
15.30-15.55

Hubert Serve
Goethe University Frankfurt, Germany

Mechanisms of oncogene and non-oncogene addiction in AML
L29
16.00-16.25

Stefanie Dimmeler
Goethe University Frankfurt, Germany

Regulation of autophagy by the histone demethylase Jmjd3
L30
16.30-16.55

Helle Ulrich
Institute of Molecular Biology, Mainz, Germany

Features of polyubiquitin chains in replicative DNA damage bypass
L31
17.00-17.30 Coffee break
Foyer building 22
17.30-17.55

Xin Lu
Ludwig Institute for Cancer Research Oxford, UK

Introducing STRaNDs: Shuttling Transcriptional Regulators that are Non-DNA binding
L32
18.00-18.25

Moshe Oren
Weizmann Institute, Israel

Regulation of proteostasis by the p53 network
L33
18.30-18.55

Volker Dötsch
Goethe University Frankfurt, Germany

Mechanism of inhibition and activation of Tap63a in oocytes
L34
19.00-19.25

Karl-Peter Hopfner
Ludwig Maximilians University Munich, Germany

Integrated ATP dependent mechanism for RIG-I's distinction between self and non-self RNA
L35
19.30

Bus transfer from conference venue
Farewell dinner (Campus Westend)

Thursday, July 7th
Session V

Targeting of ubiquitination and autophagy
Chairs: Xin Lu and Hubert Serve

Lecture hall 22-1
09.00-09.25

Yosef Yarden
Weizmann Institute, Israel 

Roles for receptor degradation in cancer therapy
L36
09.30-09.55

Krishnaraj Rajalingam
Johannes Gutenberg University Mainz, Germany

Ubiquitin dependent regulation of cell shape, migration and differentiation
L37
10.00-10.15

Daniela Krause             
Georg Speyer Haus, Germany

Quality control in cancers: Some cancers are more equal than others
L38
10.20-10.35

Yogesh Kulathu
MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK

Regulation of ubiquitin signaling by deubiquitinating enzymes
L39
10.40-10.55

Michael Potente
Max Planck Institute for Heart and Lung Research, Germany

Regulation of angiogenic signal transduction by deubiquitinating enzymes
L40
11.00-11.30 Coffee break
Foyer building 22
11.30-11.55

Florian Greten
Georg Speyer Haus, Germany

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation
L41
12.00-12.25

Kevin Ryan 
Cancer Research UK, Beatson Institute, UK

Mechanisms of macroautophagy in cell death and cancer
L42
12.30-12.55

Stefan Knapp
Goethe University Frankfurt, Germany
Targeting opportunities in autophagy

L43
13.00-13.40

Keynote lecture
Philip Cohen
MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK

The role of TRAF6 and Lys63-linked ubiquitin chains in regulating the MyD88 signaling network.
KL4
13.45

Closing ceremony, poster prizes and remarks

 

Packed lunch and departure

 

 

 

Hosted by:

FAN FAN FAN FAN

 

We thank for kind support and donation of poster prizes: