Curriculum Vitae
| Education and professional experience | |
| Feb 2008-till date | Head, Emmy Noether Group of the DFG, Institute for Biochemistry II, Goethe University Medical School, Frankfurt. |
| May 2006-Jan 2008 | C1, Wissenschafliche Oberassistent, Junior Group leader, MSZ, University of Wuerzburg, Germany |
| 2005-2006 | Scientist, Max Planck Institute for Infections Biology, Berlin |
| 2004-2005 | Postdoc, Max Planck Institute for Infections Biology, Berlin |
| 2000-2004 | PhD Student, Max Planck Institute for Infections Biology, Berlin |
| 1995-2000 | Masters in Life Sciences, Bharathidasan University, Thiruchirapalli, Tamil Nadu, India |
| Major awards and fellowships |
| Selected for the EMMY-NOETHER PROGRAMME of the German Research Foundation (DFG) |
| AACR-AFLAC Scholar-in-Training Award 2005. |
| PhD and postdoc fellowships from the Max Planck Society |
| Travel grants from EMBO/FEBS/UNESCO and others |
| International Patents |
| Prohibitin as a target for cancer therapy. (PCT/EP2005/010339) (WO/2006/032528) |
| Publications |
| 1- Krishnamurthy KV, Krishnaraj R, Chozhavendan R, and Christopher, F.S. (2000) The programme of cell death in plants and animals - A comparison. Current Science 79 (9): 1169-1181. |
| 2- Rajalingam K, Al-Younes H, Muller A, Meyer TF, Szczepek AJ, Rudel T. (2001) Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis. Infection and Immunity 69 (12):7880-8. |
| 3- Machuy N, Rajalingam K, Rudel T. (2004) Caspase mediated cleavage of c-Abl is required during cisplatin induced apoptosis. Cell Death and Differentiation 11(3):290-300. |
| 4- Machuy N*, Thiede B*, Rajalingam K, Dimmler C, Thieck O, Meyer TF, Rudel T. (2005) A global approach combining proteome analysis and phenotypic screening with RNA interference yields novel apoptosis regulators. Molecular and Cellular Proteomics (1):44-55. |
| 5- Krishnaraj Rajalingam, Christian Wunder, Volker Brinkmann, Yuri Churin, Mirko Hekman, Claudia Sievers, Ulf R. Rapp, Thomas Rudel. (2005) Prohibitin is required for Ras induced Raf-MEK-ERK activation and epithelial cell migration. Nature Cell Biology 7(8):837-43. Cover feature (image) for August 2005 issue of NCB What is in a name? (2005) Nature Reviews Molecular Cell Biology 6, 674-675 doi: 10.1038/nrc1731. (Evaluated by faculty of 1000 biology & medicine, highlighted in EMBO encounters) |
| 6- Krishnaraj Rajalingam and Thomas Rudel. (2005) Ras-Raf signaling needs prohibitin. Cell Cycle 4(11):1503-5. |
| 7- Nicole Paland, Krishnaraj Rajalingam, Nikolaus Machuy, Agnes Szczepek, Wolfgang Wehrl and Thomas Rudel. (2006) NF-kappaB and inhibitor of apoptosis proteins are required for apoptosis resistance of epithelial cells persistently infected with Chlamydophila pneumoniae. Cellular Microbiology 8(10):1643-55. |
| 8- Krishnaraj Rajalingam, Manu Sharma, Nicole Paland, Oliver Thieck, Monique Oswald, Nikolaus Machuy and Thomas Rudel. (2006) IAP-IAP complexes required for apoptosis resistance of C.trachomatis infected cells. PloS Pathogens 2(10):e114. |
| 9- Oliver kepp§, Krishnaraj Rajalingam§, Sonja Kimmig, and Thomas Rudel. (§Equal contribution) (2007) Bax and Bak are functionally non redundant during Neisseria gonorrhoea and DNA damage- induced apoptosis. EMBO journal 26(3):825-34. |
| 10- Krishnaraj Rajalingam, Ralf Schreck, Ulf R Rapp, Stefan Albert. (2007) Ras oncogene and effectors. Biochimica et Biophysica Acta-Molecular Cell Research 1773(8):1177-95. |
| 11- Krishnaraj Rajalingam, Monique Oswald, Kathleen Gottschalk, Thomas Rudel. (2007) Smac is required for effector caspase activation during apoptosis in human cells. Apoptosis 12(8):1503-10. |
| 12- Anatoly Samoylenko, Nadiya Byts, Krishnaraj Rajalingam, Nico von Ahsen, Ulf R. Rapp, Hannelore Ehrenreich and Anna-Leena Sirén. (2008) Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK1/2 signalling. Cellular Signalling 20(1):154-62. |
| 13- Krishnaraj Rajalingam*, Manu Sharma*, Christine Wolkewitz, Monique Oswald, Christopher J. Froelich, Thomas Rudel. (2008) Mcl-1 is a key regular of apoptosis resistance in Chlamydia trachomatis infected cells. PloS ONE 3(9):e3102 |
| 14- Taner Dogan, Gregory S.Harms, Mirko Hekman, Christiaan Karremann, Tripat kaur Oberoi, Emad S.Alnemri, Ulf R Rapp, Krishnaraj Rajalingam. (2008) X linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nature Cell Biology 10 (12):1447-55. |
| 15- Krishnaraj Rajalingam and Ivan Dikic (2009). Inhibitors of Apoptosis catch ubiquitin. Biochemical Journal 417(1):e1-3. |
| 16- Andreas Fischer, Angela Baljuls, Jörg Reinders, Elena Nekhoroshkova, Claudi Sibilski, Renate Metz, Stefan Albert, Krishnaraj Rajalingam, Mirko Hekman, and Ulf R. Rapp (2009) Regulation of RAF Activity by 14-3-3 Proteins –RAF Kinases Associate Functionally with both Homo- and Heterodimeric forms of 14-3-3 Proteins. Journal of Biological Chemistry 284(5):3183-94. |
| 17- Oliver Kepp, Kathleen Gottschalk, Yuri Churin, Krishnaraj Rajalingam, Volker Brinkmann, Nikolaus Machuy, Guido Kroemer, Thomas Rudel. (2009) Bim and Bmf Synergize to Induce Apoptosis in Neisseria Gonorrhoeae Infection. (Accpeted in PloS pathogens) |
| Invited lectures (selected) |
| 1- How to count on counting apoptosis? – DRFZ invited lecture, Berlin |
| 2- Conducted and co-chaired a workshop session on apoptosis with Prof. Dr. Krammer for the German society of Immunology, 2003. |
| 3- Represented Max Planck society for the Max Planck-India interaction meeting and delivered a talk on “Bacterial modulation of host cell apoptosis” at NCBS, Bangalore, India. (March 2005). |
| 4- Invited lecture on “Prohibitin-a new component of the old pathway”- Beatson Institute for cancer research, Glasgow, UK (Aug 2005) |
| 5- Invited speaker for the external seminar series for Institute for Cancer research UK, London (Sep 2005) |
| 6- Invited speaker for SFB 581 seminar series- on United they stand – the cross regulation of IAPs, Wuerzburg, (Oct 2005). |
| 7- Invited to lecture and co chair a session in the International Symposium on Translational Research: APOPTOSIS & CANCER held in Trivandrum, Kerala, India (Dec, 2005). |
| 8- Invited for a research seminar “Role of prohibitin in RAS signaling and modulation of host cell apoptosis by bacterial pathogens” in GENENTECH, USA (2007) |
| 9- Selected for a short talk in the EMBO meeting on Cellular Signalling and Molecular medicine in Cavtat, Croatia (May 29-Jun 4 ’08) |
| 10- Selected for short talk in the EMBO workshop on “Can epigenetics influence reprogramming & metastatic progression?” Bad staffelstein (Oct 6-9’08). |