About us
Normal cell growth, development and turn over are tightly controlled by a myriad of signalling networks encompassing various proteins. The major focus of our group is to understand how cell death/survival signaling is orchestrated in normal and tumour cells. Deregulation of these cascades leads to several pathological conditions including cancer. In particular, we are interested in understanding the biochemistry of RAF kinases and Inhibitors of Apoptosis (IAPs) and their role in modulating various cellular processes. We employ a wide range of techniques and cell culture models to address our scientific questions.
Selected publications
1- Taner Dogan, Gregory S.Harms, Mirko Hekman, Christiaan Karremann, Tripat kaur Oberoi, Emad S.Alnemri, Ulf R Rapp, Krishnaraj Rajalingam. (2008) X linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nature Cell Biology 10 (12):1447-55.
2- Oliver kepp§, Krishnaraj Rajalingam§, Sonja Kimmig, and Thomas Rudel. (§Equal contribution) (2007) Bax and Bak are functionally non redundant during Neisseria gonorrhoea and DNA damage- induced apoptosis. EMBO journal 26(3):825-34.
3- Krishnaraj Rajalingam, Manu Sharma, Nicole Paland, Oliver Thieck, Monique Oswald, Nikolaus Machuy and Thomas Rudel. (2006) IAP-IAP complexes required for apoptosis resistance of C.trachomatis infected cells. PloS Pathogens 2(10):e114.
4- Krishnaraj Rajalingam, Christian Wunder, Volker Brinkmann, Yuri Churin, Mirko Hekman, Claudia Sievers, Ulf R. Rapp, Thomas Rudel. (2005) Prohibitin is required for Ras induced Raf-MEK-ERK activation and epithelial cell migration. Nature Cell Biology 7(8):837-43.
