• Krishnaraj Rajalingam was born and brought up in Mayiladuthurai, India.   After receiving his Masters in Life sciences from Bharathidasan University, Thiruchirapalli, India he moved to Germany to work with Profs. Thomas Rudel and Thomas Meyer at the Max Plnack Institute for Infections Biology (MPIIB) in Berlin. After obtaining his PhD, he continued at MPIIB as a scientist before moving to MSZ at the University of Würzburg to start with his own group. He subsequently moved to Frankfurt and currently he is heading an Emmy Noether Group of the DFG at the Institute. Krishna’s scientific interests are in understanding the molecular signalling controlling cell death/survival and more recently on cell migration.

  Krishnaraj Rajalingam Group leader

  Resume of Krishnaraj Rajalingam +

  Education and professional experience
  2008-	Head, Emmy Noether Group of the DFG Institute of Biochemistry II Goethe University Medical School, Frankfurt
  2006 - 2008	C1, Wissenschaflicher Oberassistent Junior Group leader Institute of edical Radiation and Cell Research (MSZ) University of Wuerzburg, Germany
  2005 - 2006	Scientist, Max Planck Institute for Infections Biology, Berlin
  2004-2005	Postdoc, Max Planck Institute for Infections Biology, Berlin
  2000-2004	PhD Student, Max Planck Institute for Infections Biology, Berlin
  1995-2000	Masters in Life Sciences, Bharathidasan University, Thiruchirapalli, Tamil Nadu, India

  Major awards and fellowships

  Selected for the EMMY-NOETHER PROGRAMME of the German Research Foundation (DFG)

  BOGS Stipend of the German Academy of Sciences, Leopoldina

  AACR-AFLAC Scholar-in-Training Award 2005.

  PhD and Scientist fellowships from the Max Planck Society

  Travel grants from EMBO/FEBS/UNESCO

  International Patents

  Prohibitin as a target for cancer therapy. (PCT/EP2005/010339) (WO/2006/032528)

  Invited lectures (selected)

  How to count on counting apoptosis – DRFZ invited lecture, Berlin

  Conducted and co-chaired a workshop session on apoptosis with Prof. Dr. Krammer for the German society of Immunology, 2003.

  Represented Max Planck society for the Max Planck-India interaction meeting and delivered a talk on “Bacterial modulation of host cell apoptosis” at NCBS, Bangalore, India. (March 2005).

  Invited lecture on “Prohibitin-a new component of the old pathway”- Beatson Institute for cancer research, Glasgow, UK (Aug 2005)

  Invited speaker for the external seminar series for Institute for Cancer research UK, London (Sep 2005)

  Invited speaker for SFB 581 seminar series- on United they stand – the cross regulation of IAPs, Wuerzburg, (Oct 2005).

  Invited to lecture and co chair a session in the International Symposium on Translational Research: APOPTOSIS & CANCER held in Trivandrum, Kerala, India (Dec, 2005).

  Invited for a research seminar “Role of prohibitin in RAS signaling and modulation of host cell apoptosis by bacterial pathogens” in GENENTECH, USA (2007)

  Selected for a short talk in the EMBO meeting on Cellular Signalling and Molecular medicine in Cavtat, Croatia (May 29-Jun 4 ’08)

  Selected for short talk in the EMBO workshop on “Can epigenetics influence reprogramming & metastatic progression?” Bad staffelstein (Oct 6-9’08).

  invited for a short talk and to co-chair a session on Apoptosis in the Leopoldina symposium on “Evolution of programmed Cell Death in Infection and Immunity” (Sep18-20,2009).

  Publications

  Krishnamurthy KV, Krishnaraj R, Chozhavendan R, and Christopher, F.S. (2000) The programme of cell death in plants and animals - A comparison. Current Science 79 (9): 1169-1181.

  Rajalingam K, Al-Younes H, Muller A, Meyer TF, Szczepek AJ, Rudel T. (2001) Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis. Infection and Immunity 69 (12):7880-8.

  Machuy N, Rajalingam K, Rudel T. (2004) Caspase mediated cleavage of c-Abl is required during cisplatin induced apoptosis. Cell Death and Differentiation 11(3):290-300.

  Machuy N*, Thiede B*, Rajalingam K, Dimmler C, Thieck O, Meyer TF, Rudel T. (2005) A global approach combining proteome analysis and phenotypic screening with RNA interference yields novel apoptosis regulators. Molecular and Cellular Proteomics (1):44-55.

  Krishnaraj Rajalingam, Christian Wunder, Volker Brinkmann, Yuri Churin, Mirko Hekman, Claudia Sievers, Ulf R. Rapp, Thomas Rudel. (2005) Prohibitin is required for Ras induced Raf-MEK-ERK activation and epithelial cell migration. Nature Cell Biology 7(8):837-43. Cover feature (image) for August 2005 issue of NCB What is in a name? (2005) Nature Reviews Molecular Cell Biology 6, 674-675 doi: 10.1038/nrc1731. (Evaluated by faculty of 1000 biology & medicine, highlighted in EMBO encounters)

  6- Krishnaraj Rajalingam and Thomas Rudel. (2005) Ras-Raf signaling needs prohibitin. Cell Cycle 4(11):1503-5.

  Nicole Paland, Krishnaraj Rajalingam, Nikolaus Machuy, Agnes Szczepek, Wolfgang Wehrl and Thomas Rudel. (2006) NF-kappaB and inhibitor of apoptosis proteins are required for apoptosis resistance of epithelial cells persistently infected with Chlamydophila pneumoniae. Cellular Microbiology 8(10):1643-55.

  Krishnaraj Rajalingam, Manu Sharma, Nicole Paland, Oliver Thieck, Monique Oswald, Nikolaus Machuy and Thomas Rudel. (2006) IAP-IAP complexes required for apoptosis resistance of C.trachomatis infected cells. PloS Pathogens 2(10):e114.

  Oliver kepp§, Krishnaraj Rajalingam§, Sonja Kimmig, and Thomas Rudel. (§Equal contribution) (2007) Bax and Bak are functionally non redundant during Neisseria gonorrhoea and DNA damage- induced apoptosis. EMBO journal 26(3):825-34.

  Krishnaraj Rajalingam, Ralf Schreck, Ulf R Rapp, Stefan Albert. (2007) Ras oncogene and effectors. Biochimica et Biophysica Acta-Molecular Cell Research 1773(8):1177-95.

  Krishnaraj Rajalingam, Monique Oswald, Kathleen Gottschalk, Thomas Rudel. (2007) Smac is required for effector caspase activation during apoptosis in human cells. Apoptosis 12(8):1503-10.

  Anatoly Samoylenko, Nadiya Byts, Krishnaraj Rajalingam, Nico von Ahsen, Ulf R. Rapp, Hannelore Ehrenreich and Anna-Leena Sirén. (2008) Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK1/2 signalling. Cellular Signalling 20(1):154-62.

  13- Krishnaraj Rajalingam*, Manu Sharma*, Christine Wolkewitz, Monique Oswald, Christopher J. Froelich, Thomas Rudel. (2008) Mcl-1 is a key regular of apoptosis resistance in Chlamydia trachomatis infected cells. PloS ONE 3(9):e3102

  Taner Dogan, Gregory S.Harms, Mirko Hekman, Christiaan Karremann, Tripat kaur Oberoi, Emad S.Alnemri, Ulf R Rapp, Krishnaraj Rajalingam. (2008) X linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nature Cell Biology 10 (12):1447-55.

  Krishnaraj Rajalingam and Ivan Dikic (2009). Inhibitors of Apoptosis catch ubiquitin. Biochemical Journal 417(1):e1-3.

  Andreas Fischer, Angela Baljuls, Jörg Reinders, Elena Nekhoroshkova, Claudi Sibilski, Renate Metz, Stefan Albert, Krishnaraj Rajalingam, Mirko Hekman, and Ulf R. Rapp (2009) Regulation of RAF Activity by 14-3-3 Proteins –RAF Kinases Associate Functionally with both Homo- and Heterodimeric forms of 14-3-3 Proteins. Journal of Biological Chemistry 284(5):3183-94.

  Oliver Kepp, Kathleen Gottschalk, Yuri Churin, Krishnaraj Rajalingam, Guido Kroemer, Thomas Rudel. (2009) Bim and Bmf dependent apoptosis during Neisseria gonorrhoea infection PloS Pathogens 5(3):e1000348.

  Philippe C. Morand, Marek Drab, Krishnaraj Rajalingam, Xavier Nassif and Thomas F.Meyer. (2009) Neisseria meningitidis differentially controls host cell motility with PilC1 and PilC2 components of type-4 pili PloS ONE, Aug 31;4(8):e6834

  Vera Kozjak-Pavlovic*, Elke A. Dian*, Michael Meinecke*, Oliver Kepp*, Katharina Ross, Krishnaraj Rajalingam, Anke Harsman, Eva Hauf, Volker Brinkmann, Ines Herrmann, Robert Hurwitz, Dirk Günther, Joachim Rassow, Richard Wagner, Thomas Rudel. (2009) Bacterial porin integrated into mitochondrial inner membrane dissipates membrane potential and sensitizes host cells to apoptosis. PloS Pathogens Oct;5(10):e1000629. Epub 2009 Oct 23.

  Wesley E. Straub, Tobias A. Weber, Birgit Schäfer, Eleonora Candi, Florian Durst, Horng Der Ou, Jan Heering, Krishnaraj Rajalingam, Gerry Melino and Volker Dötsch. (2009) The C-terminus of p63 Contains Multiple Regulatory Elements with Different Functions (Cell death &Disease- in press).

   

• Gergely Imre was born in Budapest, Hungary. He spent the school years in Budapest, where he received MSc degree in Molecular biology. He joined Ph.D program at the 1st Institute of Pathology and Experimental Cancer Research, Semmelweis Medical School, Budapest, under the supervision of Dr. Rudolf Mihalik. During his doctoral studies he worked on better understanding of the alternativ pathways of cell death regulation in cancer cells. After completing the Ph. D, he joined Dr. Krishnaraj Rajalingam’s laboratory at the Institute of Biochemistry II, Goethe University, Frankfurt am Main. His current research interest is focused on the molecular regulation of cell death pathways in pathological processes such as bacterial infections and cancer.

  Gergely Imre Postdoctoral fellow

  Resume of Gergely Imre +

  Name	Gergely Imre
  Current position	postdoctoral fellow
  Research interest	cell death regulation, molecular oncology
  Studies
  2003-2008	Ph.D. student at the Doctoral School of Pathological Sciences and Oncology, Semmelweis University, Budapest, Hungary
  2002-2004	MSc in Secondary Teacher’s Qualifications (Biology) Eötvös Loránd University, Budapest, Hungary
  1998-2003	MSc in Molecular Biology Eötvös Loránd University, Budapest, Hungary

  Publications
  Imre G, Dunai Z, Petak I, Mihalik R. Cystein cathepsin and Hsp90 activities determine the balance between apoptotic and necrotic cell death pathways in caspase compromised U937 cells. Biochim Biophys Acta 2007; 1773(10):1546-57.
  Mihalik R, Imre G, Petak I, Szende B, Kopper L. Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown. Cell Death Differ 2004;11(12):1357-60.
  Felfoldi B, Imre G, Igyarto B, Ivan J, Mihalik R, Lacko E, Olah I, Magyar A. In ovo vitelline duct ligation results in transient changes of bursal microenvironments. Immunology 2005;116(2):267-75.
  Nagy K, Petak I, Imre G, Barna G, Gezane-Csorba M, Sebestyen A, Houghton JA, Mihalik R, Kopper L. Proteasome inhibitors abolish cell death downstream of caspase activation during anti-microtubule drug-induced apoptosis in leukemia cells. Anticancer Res 2005;25(5):3321-6.
  Mihalik R, Imre G. Kaszpázok, apoptózis, sejtelhalás: (jel)útvesztőben. Orvosképzés 2006, LXXXI. évfolyam, 3. szám: 151-157
  International Prizes
  2008	EMBO poster award

   

• Armelle Takeda studied the structure and the function of sodium channels during her Master work and then during her PhD thesis. In May 2009, she received her PhD degree in Life Sciences from the University of Lausanne, Switzerland, in co-direction with the University Pierre & Marie Curie, Paris VI, France. Since May 2010, she has joined the group of Dr. Krishna Rajalingam in Frankfurt to study the role of Inhibitors of Apoptosis Proteins.

  Armelle Takeda Postdoctoral fellow

  Resume of Armelle Takeda +

  Armelle-Natsuo TAKEDA, PhD
  Education
  May 2010 – Present	Postdoctoral Fellow, Institute for Biochemistry II, Goethe-University of Frankfurt, Frankfurt-am-Main, Germany. Supervisor: Dr. Krishna Rajalingam "Investigation of the physiological roles of inhibitors of apoptosis proteins (IAPs)."
  2005 – 2009	PhD Researcher, co-working between the Department of Pharmacology & Toxicology, University of Lausanne, Switzerland, and the Centre of Biomedical Research of Bichat Hospital, University Pierre & Marie Curie, Paris VI, France. Supervisor: Prof. Laurent Schild & Dr. Alain Vandewalle
  	Investigation of functional domains of ENaC/Deg family proteins either accessible from the external or the internal side of the cell.
  Sept. 2003-Oct. 2004	Master of Cellular & Molecular Physiopathology, Centre of Biomedical Research of Bichat Hospital, University Pierre & Marie Curie, Paris VI, France. Supervisor: Dr. Alain Vandewalle Investigation of the effect of androgens on the mineralocorticoid receptor and their role in the sodium transport.
  Communications and Prizes
  20-23 Sept. 2009	Oral communication in English at the 20th Ion Channel Meeting, Presqu’île de Giens, France
  03-07 Oct. 2007	1st Poster Prize at the 6th International Symposium on “Aldosterone and ENaC: From gene to disease”, in Zermatt, Switzerland
  16-17 June 2005	Oral Communication in French at “Journées Takis Anagnostopoulos”, Faculty of Medicine Necker, Paris, France
  23 Oct. 2004	Oral Communication in English at the European Section of the Aldosterone Council (ESAC) Congress, Collège de France, Paris, France
  20-21 Sept. 2004	1st Poster Prize “Ivan Chouroulinkov” at the “Société de Pharmaco-Toxicologie Cellulaire” (SPTC) Congress, Faculty of Medicine Xavier Bichat, Paris, France
  Publications

  Armelle-Natsuo Takeda, Ivan Gaustchi, Miguel X. van Bemmelen and Laurent Schild. Cadmium Trapping in an Epithelial Sodium Channel Pore Mutant. Journal of Biological Chemistry, 282(44):31928-36, Nov. 2007.

  Armelle-Natsuo Takeda*, Grégory M. Pinon*, Marcelle Bens, Jérôme Fagart, Marie-Edith Rafestin-Oblin and Alain Vandewalle. The Synthetic Androgen Methyltrienolone (R1881) Acts as a Potent Antagonist of the Mineralocorticoid Receptor. Molecular Pharmacology, 71(2):473-82, Feb. 2007. (*, equal contributing authors)

  Yvan Pfister, Ivan Gautschi, Armelle-Natsuo Takeda, Miguel X. van Bemmelen, Stephan Kellenberger, Laurent Schild. A gating mutation in the internal pore of ASIC1a. Journal of Biological Chemistry, 281(17):11787-91, Apr. 2006.

   

• After finishing the study of Technical Biology in 2006, he started his PhD thesis at the Institute of Cell Biology and Immunology at the University of Stuttgart. In 2010 he joined the Cell Death Signaling group at the Institute of Biochenistry II. Rolf is interested in the regulation of various intracellular signaling pathways by Inhibitor of Apoptosis proteins (IAPs).	Rolf-Peter Scholz Postdoctoral fellow
  Resume of Rolf-Peter Scholz +

  Rolf-Peter Scholz
  Education
  2010	Postdoctoral fellow in the Emmy Noether Group of DFG, Institut für Biochemie II, Goethe University Medical School, Frankfurt
  2006-2010	PhD thesis: Institute of Cell Biology and Immunology, University of Stuttgart. „Regulation of the tumour suppressor protein Deleted in Liver Cancer 1 (DLC1) by phosphorylation”
  2006	Diploma thesis: Institute of Cell Biology and Immunology, University of Stuttgart. „Deleted in Liver Cancer 1, ein neues Substrat für Protein Kinase D“;
  2003	Student thesis: University of Waterloo, Canada „Characterization of the Interaction between Dbf4 and Mcm2 via Two-hybrid analysis
  Poster presentation
  2007	Gordon research conference „Mechanisms of cell signalling”, Oxford, UK
  Scholarships
  2002-2003	Exchange program Ontario/Baden-Württemberg
  2002-2003	Scholarship of the Landesstiftung Baden-Württemberg
  2007-2009	Scholarship of the Landesgraduiertenförderung
  Publications

  Scholz RP, Regner J, Theil A, Erlmann P, Holeiter G, Jahne R, Schmid S, Hausser A, Olayioye MA (2009). DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. J Cell Sci 122: 92-102

  Varrin AE, Prasad AA, Scholz RP, Ramer MD, Duncker BP (2005). A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents. Mol Cell Biol 25: 7494-504.

   

• Tripat completed her bachelor’s degree in Pharmacy in Punjabi University, Patiala in 2004. She got her Master’s degree in Pharmaceutical Biotechnology from National Institute of Pharmaceutical Education and Research under the supervision of Prof. C.S. Dey. She is currently working as a PhD student in Dr. Krishnaraj Rajalingam’s lab, mainly focusing on the study the physiological roles of Inhibitor of Apoptosis Proteins (IAPs).	Tripat Kaur Oberoi Ph.D student
  Resume of Tripat Kaur Oberoi +

  Tripat Kaur Oberoi

  Education and research experience:

  2000-2004	Bachelor’s degree in Pharmacy (B. Pharm.) from Punjabi University (Punjab), India.
  2004-2006	Master’s degree (M.S. Pharm. Biotechnology) in Prof. Chinmoy S. Dey’s lab. National Institute of Pharmaceutical Education and Research (NIPER) (Punjab), India.
  2006-2007	Project assistant in Prof. Chinmoy S. Dey’s lab. National Institute of Pharmaceutical Education and Research (NIPER) (Punjab), India.
  2008-Present	PhD student Cell Death Signaling Group (Dr. Krishnaraj Rajalingam), Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany.

  Publications:

  Taner Dogan, Gregory S. Harms, Mirko Hekman, Christiaan Karreman, Tripat Kaur Oberoi, Emad S. Alnemri, Ulf R. Rapp and Krishnaraj Rajalingam. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nat. Cell Biol. 10, 1447 - 1455 (2008).

  Awards and fellowships:

         

  2006	Gold Medal for academic excellence in M.S. (Pharm.) Biotechnology.
  2004-2006	First Rank in M.S. (I, II, III & IV) Semesters, NIPER, Mohali, INDIA.
  2004	IDMA G.P. Nair Award for academic excellence in B. Pharm.
  2004	First Rank in B. Pharm. Final year, Punjabi University, Patiala, INDIA.

   

• Juliane Mooz was born in Berlin, Germany. She studied Biology at the Julius Maximilian University, Würzburg and obtained her diploma degree in 2007. She has always been interested in scientific journalism, conveying information about the world of science to a public forum. After finishing University, she had been involved in radio broadcasting, “Talking about science“. In 2009, she joined the lab of Dr. Krishnaraj Rajalingam, studying the regulation of Rac1 and CRAF protein stability.

  Juliane Mooz Ph.D student

  Resume of Juliane Mooz +

  Personal Information
  Name	Juliane Mooz
  2000	Finishing school (Abitur) and starting to explore the world ever since the year
  Studies
  2000-2001	Social service in England
  2001-2003	Undergraduate studies in biology at Würzburg University
  2004-2007	Postgraduate studies at Würzburg University including year abroad at Umeå University, Sweden (Tumor Biology) joining Simon Tuck´s lab (c.elegans) at the UCMM fieldwork in Wales (Marine Biology) and Malaysia (Invasive Biology)
  2007	Master thesis: “Modulation of cell survival by Prohibitins” under supervision of Prof. Dr. Ulf Rapp in collaboration with Dr. K. Rajalingam, Institut für Medizinische Strahlenkunde und Zellforschung
  2008	“Talking about science” - exploring the field of scientific journalism via radio broadcast
  2009	PhD student at the Institute of Biochemistry II J. W. Goethe University Medical School Cell Death Signaling group (AG Rajalingam)

   

• Updating...	Kristina Wagner MTA
  Resume of Kristina Wagner +

  Updating...