Molecular signaling group
Head: Ivan Dikic
Our group study signaling pathways that control cell growth and differentiation and the reasons why they are deregulated in diseases such as cancerWe are interested in signaling by growth factor activated receptors and mechanisms underlying their endocytosis and degradation through actions of the scaffold protein CIN85 and the ubiquitin ligase Cbl. We also study the expanding role of ubiquitin and Ub-like modifiers in regulation of DNA repair, NFkB pathway, autophagy and cancer pathogenesis. We utilize molecular biology, cell biology and biochemistry as well as genetically altered mice and cells derived from such animals to understand how molecular signals regulate cell functions in vivo.
Office: Tel: 00 49 69 6301 5652
How to find us:
from the airport:
1. take taxi directly to the Frankfurt University hospital (UNIKLINIK) Building 75 – it is a large hospital complex and it is bets to say to a taxi driver that building 75 is behind the Blutspendedienst. The drive is approximately 15 minutes (17-20 EURO).
2. take the subway to Frankfurt central station (Hbf) then change to a tram line 12 or 21 to cross the Main river and stop at the Heinrich-Hoffmann-Strasse/Blutspendedienst station