Ivan Dikic group |
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Ivan Dikic was born and brought up in Zagreb, Croatia, where he was trained as a medical doctor, he obtained his PhD in molecular biology from the University of Zagreb while working under the supervision of Joseph Schlessinger at New York University Medical Center, USA.
He became a Group Leader at the Ludwig Institute for Cancer Research, Uppsala, Sweden moving to Frankfurt in 2002.
He is currently a Professor and Director of Institute of Biochemistry II at the Goethe University, Frankfurt, Germany and the Director of the Frankfurt Institute for Molecular life Sciences (FMLS).
He also holds a Guest Professorship at the University of Split, Croatia and is an Adjunct Investigator of the Tumour Biology Program of MedILS.
Ivan’s scientific interests are focused on how ubiquitin pathways regulate cellular processes, such as receptor-mediated endocytosis, immune responses, DNA repair, proteasomal degradation and more recently on molecular basis of selective autophagy.
Ivan Dikic
Director of IBCII
Group leader of
Molecular Signaling groupResume of Ivan Dikic +
Ivan Dikic
Johann Wolfgang Goethe University,
Medical School
Theodor-Stern-Kai 7
D-60590 Frankfurt am Main, GermanyTel: 00 49 69 6301 5652
Fax: 00 49 69 6301 5577
E-mail: Ivan.Dikic@biochem2.de
Personal Information
Date of Birth: 28.05.1966
Place of Birth: Zagreb, Croatia
Citizen of Croatia, Resident of Germany
Family Status: Married with Inga Dikic, M.D. Ph.D.
Children: Karla (1999-2002), Lovro (2001), Petra (2003), Emma (2006)Studies
1986 – 1991 Medical Doctor, University of Zagreb Medical School, Summa cum laude, 1991 – 1995 Ph.D. - Molecular Biology University of Zagreb and New York University under supervision of Prof. J. Schlessinger 1995 – 1997 Postdoctoral Fellow with Prof. Joseph Schlessinger, New York University Medical Center, New York, USA
Positions Held
1991 - 1992 International Institute for Mother and Child Health Care, Zagreb, Croatia 1992 – 1997 Research Associate at the New York University, NY, USA 1997 – 2002 Group Leader, Ludwig Institute for Cancer Research, Uppsala, Sweden 2002 – 2008 C3 Professor, Institute of Biochemistry II, Goethe University, Medical School, Frankfurt, Germany 2002 – present Professor, School of Medicine University of Split, Croatia 2005 – present Adjunct Investigator, Tumour Biology Program, MedILS, Split, Croatia 2009 – present Director, Institute of Biochemistry II, Goethe University Medical School, Frankfurt am Main, Germany 2009 – present Scientific Director of Frankfurt Institute for Molecular Life Sciences
Awards and Honors
1990 Award for Distinguished Students, University of Zagreb, Croatia 1990 Karyn Kupcinet fellowship, Weizmann Institute, Rehovot, Israel 1991 FEBS scholarship, Aarhus, Denmark 1991 Rector's Award, University of Zagreb, Croatia 1991 D. Perovic Award- Best Medical Graduate at University of Zagreb, Croatia 1997 Young Investigator Award - Gordon Conference, Il Ciocco, Italy 1997 – 2003 Research Award, Boehringer Ingelheim Fonds Germany 2000 – 2004 Award of the Strategic Funds for Young Leaders, Sweden 2002 Lilla Fernström Award, Lund, Sweden 2006 Wissenschaftspreis 2006, Glaxo-Smith-Kline-Foundation, Munich, Germany 2006 Binder Innovation Prize, German Society for Cell Biology, Braunschweig, Germany 2006 Young Cancer Researcher Award, European Association for Cancer Research, Budapest, Hungary 2006 AACR Award for Outstanding Achievement in cancer research, Washington, USA 2008 Award of the International Society of Blood Purification, Brijuni Island, Croatia 2009 Sir Hans Krebs Preis, Gesellschaft der Medizinischen Hochschule Hannover e. V., Germany
Memberships2000-present The American Association for Cancer Research 2001-present European Life Science Organization (ELSO) 2001-2003 International Union Against Cancer 2002-present German Society for Biochemistry and Molecular Biology, FEBS and IUBMB 2003-present American Association for Biochemistry and Molecular Biology (ASBMB) 2003-present German Association for Cell Biology Since 2004 European Molecular Biology Organization (EMBO)
Scientific meetings and lecturesInvited speaker at numerous Conferences and Universities in Europe, USA and Asia. Lecturer-instructor at 12 EMBO, ESF and FEBS Courses Founder and co-organizer of the Dubrovnik conferences on Signalling (1998 – 2006) Organizer of EMBO Lecture Course on Signalling and Development (Split, 2001) Organizer of the FEBS Lecture Course on Cellular Signalling (Dubrovnik, 2004) Organizer of EMBO Practical Course on Ubiquitin and SUMO (Split, 2006 and 2008) Co-chair EMBO Conference: At the joint edge of cellular (Villars-sur-Ollon, 2008) Microbiology and cell Biolgy Chair EMBO Conference: Molecular medicine and cellular signalling (Dubrovnik, 2008) MedILS Summer School: Hot topics in Protein research (Split 2008) Board member and reviewer
2002 – 2003 Scientific Advisory Board, Betagenon, Stockholm, Sweden 2003 – 2008 Editorial Board member, Journal of Biological Chemistry 2005 Highlights Advisor, Nature Reviews Molecular Cell Biology 2005 – 2009 Scientific Advisory Board member of Association for International Cancer Research 2006 Scientific Advisory Board member of IFOM, Milan 2006 – 2010 International Advisory Board member, International Institute of Molecular and Cell Biology, Warsaw, Poland 2006 Associate editor, Cancer Research 2007 Advisory Editorial Board member EMBO Journal and EMBO Reports 2007 Editorial Board member Biochemical Journal 2008 EMBO Advanced Training Centre committee member 2009 - 2012 EMBO Publication committee member 2009 - 2012 ERC Life Science panel member 2009 Landon Foundation-AACR INNOVATOR Award Scientific Review Committee 2009 - Present Chairman of Scientific Advisory Group, SCILLS (Scottish Institute for Cell Signalling), University Dundee, Dundee, Scotland
Mentor for students and educationTill 2008 Mentor for 8 Ph.D. and 6 M.Sc. students 2008 MedILS summer schools and practical courses 2004-2008 Numerous seminars, practicum for medical students in Goethe University 2003 – 2004 Seminar courses and computer-based problem solving practicum in Biochemistry at the Goethe University Medical School, Frankfurt, Germany 2000 – 2001 Graduate course in Cellular Signalling - Karolinska Institute, Hudinge, Sweden 2000 Advanced Course in “Physiology: Cellular and Molecular Aspects”, The Wenner-Gren Institute, Stockholm University, Sweden 2000 Graduate Course in Molecular Biology, Split University, Split Croatia 1999 – 2000 Graduate Course in Cell Signalling, Uppsala University, Uppsala, Sweden 1995 – 1997 Research Instructor, New York University, Medical School, NY, USA Patent
Use of EGFL7 for modulation of cells. DE 10 2007 019162.8
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Fumiyo Ikeda was born in Japan and spent one's school years in Osaka. She graduated from Dental School of Osaka University and then started a PhD course in biochemistry department of Graduate School of Osaka University.She continued research in the same department as a staff scientist for 2 years. After that she joined Ivan Dikic's Lab as a postdoc and is continuing her research to understand regulatory mechanisms of inflammatory signaling.
Resume of Fumiyo Ikeda +
Fumiyo Ikeda, PhD, DDS Educations 1993-1999 Osaka University, Dental School, Osaka, Japan Major Dentistry Degree D.D.S. (Doctor of Dental Science) 1999-2003 Osaka University, Graduate School of Dentistry, Osaka, Japan Major Molecular Biology Degree Ph. D. (Doctor of Philosophy) Dissertation The Role of JNK/c-Jun Signaling in Osteoclast Differentiation Experiences 2000-2003 Research assistant, Osaka University, Graduate School of Dentistry, Osaka, Japan 2003-2005 Postdoctoral fellow, Osaka University, Graduate School of Dentistry, Osaka, Japan 2005- present Postdoctoral fellow, Goethe University, Frankfurt, Germany Fellowships 1999-2003 The Japan Scholarship Foundation 2002-2003 The Iwadare Scholarship Foundation 2005 The Uehara Memorial Foundation/ Research Fellowship 2005-2007 The Alexander von Hunboldt-Stiftung/ Research Fellowship 2008-2010 JSPS Postdoctoral Fellow for Research Abroad
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Nicola Crosetto received his M.D. degree from the University of Pavia, Italy, in 2003 and his Specialization in Medical Oncology from the University of Torino, Italy, in 2007. Since January 2008 he is officially enrolled in the Ph.D. program in Molecular and Systems Biology at the University of Pavia, Italy, while conducting his research work at the Institute of Biochemistry II as a post-doctoral fellow. His scientific interests span any broad question in biology that can be addressed with cellular and biochemical methods. More specifically, he has been working on the regulation of DNA damage responses by ubiquitin.
Resume of Nicola Crosseto +
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Nicola Crosetto Educations 2003 Doctor in medicine, University of Pavia, IT, 110/110 cum laude 2004-2007 Trainee in biochemistry and molecular biology, Institute for Biochemistry II, Goethe University Hospital, Frankfurt am Main, DE 2007 Specialist in medical oncology, University of Torino, IT, 70/70 2008- present PhD student in molecular and systems biology, Institute for Biochemistry II, Goethe University Hospital, Frankfurt am Main, DE and Department of Bioengineering, University of Pavia, IT Grants and awards 2009 Young researcher award, “C. Golgi” Foundation, Pavia, IT 2008 Deutsche Forschungsgemeinschaft (DFG) funding on the project: “Induction of pluripotency by protein gain-of-function in cloned mouse embryos” (http://www.spp1356.de/project-area-b/xxx/) Co-applicant with Dr. Michele Boiani, Max-Planck Institute for Molecular Biomedicine, Münster, DE. 2006 Young researcher award, “G. Costa” Association against cancer, Ivrea, IT 2005 Short-term research grant, Center for Communication and Research, Pavia, IT 2005 Best medical graduate, Collegio Ghislieri, University of Pavia, Pavia, IT
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David studied Medical Biochemistry at the University of Glasgow and completed a one-year placement in the protein biochemistry department at GlaxoSmithKline, Harlow, UK.
He graduated in 2003 and started his PhD studies at the Beatson Institute for Cancer Research, Glasgow under the supervision of Prof. Margaret Frame.
This was a collaborative study with Prof. Miles Houslay (University of Glasgow) aimed at investigating the effect of cyclic-AMP on colon cancer survival.
David completed his PhD in October 2007 and started his post-doctoral studies in February 2008 with Prof. Ivan Dikic’s lab in Frankfurt, Germany.
David’s current research interests are focused on understanding how the process of autophagy is regulated and how specific proteins/organelles are targeted for degradation.Resume of David McEwan +
Name David George McEwan Education Oct. 2003 – Sept. 2007 Beatson Institute for Cancer Research Doctor of Philosophy (PhD) in Biochemistry and Molecular Biology Title Cyclic AMP modulation and its Effects on Chemo-resistant Colon Cancer cell Proliferation and Survival.Supervisors Prof. Margaret Frame and Prof. Miles HouslayAims Addressing the role of the second messenger cAMP in the regulation of colon cancer proliferation and survival. This work will provide further insights into the compartmentalised signalling pathways that regulate cAMP and its effects on proliferation with a view to developing new therapeutic strategies to combat colon cancer. For a detailed description of my PhD project please see appendix.October 1998 – June 2003 University of Glasgow MSci Medical Biochemistry (with work placement), Upper second class Final year project To study the effects of the immunophillin XAP2 on the protein kinase A (PKA) mediated phosphorylation and activity of a phosphodiesterase isoform, PDE4A5, under conditions that maximally activate PKA.Dissertation Purine Alkaloids: Importance to plants & their effects on humans. August 1992 - June 1998 St Andrews Academy, Paisley CSYS Maths, 6 Highers (English B, biology A, chemistry B, maths B, physics B, technological studies B and computing studies B)Professional experience October 2001 – September 2002 GlaxoSmithKline, Harlow, Essex Protein expression and purification group. During my industrial placement I was an integral part of a team that helped purify proteins that were required for various studies in the target to lead phase of drug development. The placement supplied me with the basic laboratory skills that have provided the foundations from which I have been able to build upon. Techniques employed included ion exchange chromatography, gel filtration and protein refolding to purify proteins to various degrees. LC/MS, peptide mass fingerprinting and N-terminal sequencing were also used to identify and aid the characterisation of purified proteins.Publications Novak I*, Kirkin V*, McEwan DG*, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichtert A, Terzic J, Doetsch V, Paul N, Dikic I. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Reports, 2010, in press. (*Equal contributing authors)Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell. 2009; 34(3):259-69Kirkin V, Lamark T, Sou YS, Bjorkoy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Overvatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T. A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates. Mol Cell 2009; 33: 505-16.Sandilands E, Akbarzadeh S, Vecchione A, McEwan DG, Frame MC, Heath JK. Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors. EMBO Rep 2007; 8: 1162-9. McEwan DG, Brunton VG, Baillie GS, Leslie NR, Houslay MD, Frame MC. Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. Cancer Res 2007; 67: 5248-57. Bolger GB, Peden AH, Steele MR, MacKenzie C, McEwan DG, Wallace DA, Huston E, Baillie GS, Houslay MD. Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. J Biol Chem 2003; 278: 33351-63.
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Sigrid Skånland earned her PhD in Oslo, Norway, studying intracellular transport under the supervision of Prof. Kirsten Sandvig. She is currently working as an EMBO fellow in the lab of Prof. Ivan Dikic, with main research interest being ubiquitin signals in the immune response.
Resume of Sigrid Skånland +
Name Sigrid S. Skånland Education 2009- Postdoc in Prof. Ivan Dikic’s lab. Institute of Biochemistry II, Johan Wolfgang Goethe University, Frankfurt, Germany 2005-2008 Ph.D-student in Prof. Kirsten Sandvig’s lab. The Norwegian Radium Hospital, University of Oslo, Oslo, Norway: “Mechanisms in intracellular transport of toxins” 2004-2005 Master’s degree in Molecular Biology in Prof. Kirsten Sandvig’s lab. The Norwegian Radium Hospital, University of Oslo, Oslo, Norway: “The phosphatidylinositol 3-kinase hVps34 modulates endosome to Golgi transport of ricin.” 1999-2002 Cand. mag. in Biology. Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway. Training/courses 2007 Live cell imaging course. IMBV/EMBIO, Oslo, Norway. 2007 Confocal microscopy. Molecular Imaging Center, Bergen, Norway. 2006 Visiting student (3 months) in Prof. Tom Rapoport’s lab, Dept. of Cell Biology, Harvard Medical School, Boston, MA, USA. 2005 FEBS/EMBO advanced lecture course: Cellular and Molecular Biology of Membranes. Corsica, France. Fellowships 2009- EMBO Long term fellowship Publications Skånland SS, Wälchli S, Brech A, Sandvig K (2009): SNX4 in complex with clathrin and dynein: implications for endosome movement. PLoS One, 4(6):e5935.
Wälchli S, Åsheim HC, Skånland SS, Spilsberg B, Torgersen ML, Rosendal KR, Sandvig K (2009): Characterization of Syk and clathrin interaction upon Shiga toxin binding. Cell Signal, (7):1161-8. Skånland SS, Wälchli S, Sandvig K: arrestins attenuate p38 mediated endosome to Golgi transport. (2009): Cell Microbiol, Jan 21. Wälchli S,* Skånland SS,* Gregers TF, Lauvrak SU, Torgersen ML, Ying M, Kuroda S, Maturana A, Sandvig K (2008): The Mitogen-activated Protein Kinase p38 Links Shiga Toxin-dependent Signaling and Trafficking. Mol Biol Cell, 19, 95-104.
*Equal contributionMénétret JF, Schaletzky J, Clemons WM Jr, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW (2007): Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Mol Cell, 28, 1083-92. Utskarpen A, Slagsvold HH, Dyve AB, Skånland SS, Sandvig K (2007): SNX1 and SNX2 mediate retrograde transport of Shiga toxin. Biochem Biophys Res Commun, 358, 566-70. Torgersen ML, Wälchli S, Grimmer S, Skånland SS, Sandvig K (2007): Protein kinase Cdelta is activated by Shiga toxin and regulates its transport. J Biol Chem, 282, 16317-28. Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K (2007): Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins. Traffic, 8, 297-309.
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Tobias Kensche came to Frankfurt to study Biology and he finished his diploma degree in 2006 (equivalent to Masters degree). He studied a diverse range of topics including Anthropology and Cell Biology. Tobias’s diploma thesis was conducted under the supervision of Prof. H. D. Osiewacz, where he investigated the molecular mechanisms of aging, and in particular, the role of small mitochondrial HSPs in the fungus Podospora anserina. In 2007 he started his PhD in the lab of Prof. Ivan Dikic at the Institute of Biochemistry II, Frankfurt. Tobias is currently investigating the role of Ubiquitin and Ubiquitin binding domains (UBDs) in inflammatory signaling pathways.
Resume of Tobias Kensche +
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Tobias Kensche Educations 2000-2006 Diploma in Biology (Institute of Molecular Biosciences, Prof. H. D. Osiewacz) Johann Wolfgang Goethe-University Frankfurt am Main Since 2007 Ph.D.-Student at the Institute of Biochemistry II J. W. Goethe University Medical School In Ivan Dikic’ group: Molecular signaling.
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Resume of Yonathan L. Deribe +
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Yonathan Lissanu Deribe Educations Sept 1995 to July 2001 Study of medicine in Gondar College of Medical Sciences, Ethiopia
Earned, Doctor of Medicine (MD) degreeOct 2002 to August 2004, International Masters Program in Molecular and Cellular Biology, University
of Heidelberg, GermanySept 2004 till present, PhD student in the institute of biochemistry II, Johan Wolfgang Goethe
University, Frankfurt, GermanyProject Summary
Binding of epidermal growth factor (EGF) to its cognate receptor (EGFR) leads to the assembly of receptor-associated signalling complexes involved in the regulation of crucial cellular functions. Following activation, the primary mechanism of signal attenuation is through receptor endocytosis and subsequent degradation. Defects in this signalling pathway are known to play major roles in development of tumors. I am studying novel regulatory mechanisms in the endocytic trafficking of the EGFR using molecular and cellular techniques.
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Philipp Wild studied Biochemistry at the Eberhard Karls University, Tübingen and obtained his diploma degree in 2007. He did his diploma work under the supervision of Dr. Antonin at the Friedrich Miescher Laboratory of the Max Planck Society investigating the molecular mechanism underlying the nuclear import of Cyclin B1. In 2008 he joined the lab of Prof. Ivan Dikic as a PhD student, studying the role of autophagy receptors in immune signaling.
Resume of Philipp Wild +
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Philip Wild Educations 2008 PhD student at the Institute of Biochemistry II J. W. Goethe University Medical School Ivan Dikic group: Molecular Signaling 2006 - 2007 Diploma thesis under supervision of Dr. Antonin at the Friedrich Miescher Laboratory in Tübingen. Title of Diploma thesis: „Investigation of the nuclear import mechanism of Cyclin B1”. 2003-2004 Academic year at the Max-Planck-Institute of Biochemistry, Martinsried 2001-2006 Study of Biochemistry at the Eberhard Karls University of Tübingen 2000 Abitur at the Hegel-Gymnasium, Stuttgart 1981 born 23.4.1981 in Stuttgart, Germany
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Magda (Marzena) Bienko was born in a small town of Poland and moved to Krakow to study Biotechnology at the Jagiellonian University. During her study she visited the lab of Ivan Dikic for an internship and joined his group to do her diploma work as well as the PhD. Her interest is genomic stability and the role of ubiquitin signaling in its maintenance. In particular, she has been focusing on the role of ubiquitylation and Ub-binding in the process of tolerating DNA damage during its replication, called Translesion Synthesis.
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Marzena Bienko Educations 2000-2005 Faculty of Biotechnology, Jagiellonian University, Cracow, Poland 2005 Master degree in Biotechnology 2005-present PhD studies in the group of Ivan Dikic Fellowships 2005-2007 Ernst Schering Foundation Scholarship 2007-2009 Josef Buchmann Scholarship Awards July 2006 2nd place in the “Young Cell Signaller” competition organized by Upstate, Dundee, UK Project description
I¹m interested in the regulation of DNA damage tolerance processes by ubiquitin. After focusing on the role of non-covalent interactions between Y-family DNA polymerases and ubiquitin I now study the function of covalent interactions in the form of the monoubiquitylation of these proteins.
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Alexis Rozenknop studied biochemistry at the University of Toulouse, France. To complete his master degree in "Structural Biology and Proteomics", he accomplished a 8 month trainee at Sanofi-Aventis, Frankfurt, Germany, working on "Protein-Ligand interactions by STD-NMR".
Since january 2007, he has started his PhD, "Functionnal and structural studies of Ubiquitin Like Proteins", as a full collaboration between Prof. Dikic and Prof. Doestch at the University of Frankfurt.
In his project, Alexis is interested in structures and dynamics of Ubiquitin Like Proteins involved in autophagy as well as binding studies with different ligands using techniques as NMR or ITC.Resume of Alexis Rozenknop +
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Alexis Rozenknop Educations 2007-current: PhD in Biochemistry: “Functionnal and Structural Studies on Ubiquitin Like Protein” at University of Frankfurt, Germany 2005-2006: 2nd year Master Program of Structural Biochemistry and Proteomics, at University of Toulouse, France 2004-2005: 1st year Master Program of Biochemistry-Biotechnologies at University of Toulouse, France 2003-2004: Bachelor’s degree in Biochemistry at University of Toulouse, France Publications Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichtert A, Terzic J, Doetsch V, Paul N, Dikic I. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Reports 2010, 11(1):45-51 Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I. Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J 2007, 26:3451-62
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Resume of Birgit Stein +
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Birgit Stein Educations 1977-1979 Eudard Stieler Schule, Fulda, Germany Major: Berufsfachschule Ernährung Degree: Intermediate Highschool 1980-1982 Albrecht Thaer Schule, Celle, Germany Major: Small Animal Breeding Degree: Agricultural Technical Assistent (LTA) Experiences 4/2003-7/2003 Research Technician Zement und Kalkwerke Otterbein, Müs, Germany 08/1983 – 10/1988 Research Technician Deutsches Primatenzentrum, Göttingen, Germany 11/1988 – 09/1989 Research Technician New England Primate Research Center, Harvard Medical School, Southborough, MA, USA 01/1990 – 06/1992 Research Technician Pulmonary Center, Boston Universitiy,School of Medicine, Boston, MA, USA 06/1992 – 05/1997 Research Associate Department of Biology, Union College, Schenectady, NY, USA 07/1997 – 10/2003 Research Associate (Technische Assistentin), David Axelrod Institute for Public Health, New York State Department of Health, Albany, NY, USA 10/1999 – 10/2003 Telefon Interviewer Wadsworth Center, State Department of Health, Albany, NY, USA (part time) 11/2003 – 11/2006 Research Associate II UMASS Medical School, Worcester, MA, USA 01/2007 – Technische Laborleiterin Institut für Biochemie II, AG Dikic, Goethe Universität Frankfurt, Frankfurt am Main Deutschland PUBLICATIONS: Chaturvedi V, Fan J, Stein B, Behr MJ, Samsonoff WA, Wickes BL, Chaturvedi S. 2002. Molecular genetic analyses of mating pheromones reveals intervariety mating/hybridization in Cryptococcus neoformans. Infection and Immunity. 70: 5225-5325 Chaturvedi S, Rodeghier B, Fan J, McCleland CM, Wickes BL & Chaturvedi V. 2000. Direct PCR of Cryptococcus neoformans MATalpha and MATa pheromones to determine mating type, ploidy and variety: A tool for epidemiological and molecular pathogenisis studies. Journal of Clinical Microbiology. 38: 2007-2009 Chaturvedi V, Ramani R, Gromadzki S, Rodeghier B, Chang H-G & Morse DL. 2000. Coccidioidomycosis in New York State. Emerging Infectious Diseases. 6: 25-29 Salvo J, Rodeghier B, Rubin A & Troischt T. 1998 Optional Introns in mitochondrial DNA of Podospora anserina are the primary source of observed size polymorphisms. Fungal genetics and Biology. 23: 162-168.
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