Members of Molecular signaling group

Ivan Dikic

Ivan Dikic was born and brought up in Zagreb, Croatia, where he was trained as a medical doctor, he obtained his PhD in molecular biology from the University of Zagreb while working under the supervision of Joseph Schlessinger at New York University Medical Center, USA.
He became a Group Leader at the Ludwig Institute for Cancer Research, Uppsala, Sweden moving to Frankfurt in 2002.
He is currently a Professor and Director of Institute of Biochemistry II at the Goethe University, Frankfurt, Germany and the Director of the Frankfurt Institute for Molecular life Sciences (FMLS).
He also holds a Guest Professorship at the University of Split, Croatia.
Ivan’s scientific interests are focused on how ubiquitin pathways regulate cellular processes, such as receptor-mediated endocytosis, immune responses, DNA repair, proteasomal degradation and more recently on molecular basis of selective autophagy.

Ivan Dikic
IBCII Director
Group leader

Education

1995 – 1997	Postdoctoral Fellow, New York University Medical Center, New York, USA
1991 – 1995	Ph.D. - Molecular Biology University of Zagreb and New York University under supervision of Prof. J. Schlessinger
1986 – 1991	Medical Doctor, University of Zagreb Medical School, Summa cum laude

Positions Held

2009 –	Scientific Director, Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University Frankfurt am Main, Germany
2009 –	Director, Institute of Biochemistry II, Goethe University Medical School, Frankfurt am Main, Germany
2005 – 2010	Adjunct Investigator, Tumour Biology Program, MedILS, Split, Croatia
2002 –	Professor, School of Medicine University of Split, Croatia
2002 – 2008	Professor, Institute of Biochemistry II, Goethe University, Medical School, Frankfurt am Main, Germany
1997 – 2002	Group Leader, Ludwig Institute for Cancer Research, Uppsala, Sweden
1992 – 1997	Research Associate at the New York University, NY, USA
1991 – 1992	Intern, International Institute for Mother and Child Health Care, Zagreb, Croatia

Professional Activities

2012 –	Vice-Speaker and Member of the Board of Directors of the Cluster of Excellence for Macromolecular Complexes, Frankfurt am Main, Germany
2011 – 2012	Speaker of the Frankfurt Autophagy Network, funded by the Goethe University, Frankfurt am Main, Germany
2010 – 2014	Member of the Organizing team for Frankfurt Cancer Institute (FCI), funded by the German Consortium for Translational Cancer Research
2010 - 2014	Executive Committee Member, European Association for Cancer Research (EACR)
2010 – 2013	Member of the Board of Directors, LOEWE Centrum for Gene and Cell Therapy, Frankfurt am Main, Germany
2009 –	Chairman of Scientific Advisory Group, SCILLS (Scottish Institute for Cell Signalling), Dundee, Scotland
2009 –	Member of the Board of Directors, Cluster of Excellence Macromolecular Complexes, Frankfurt am Main, Germany
2009 – 2014	ERC Life Science panel member
2009 – 2012	EMBO Publication committee member
2009 – 2012	EMBO Advanced Training Centre committee member
2009 – 2012	Member of the Board of Directors, LOEWE Oncology signalling program, Frankfurt am Main, Germany
2009 – 2012	Landon Foundation - AACR INNOVATOR Award Scientific Review Committee, Washington

Memberships

2010	German National Academy of Sciences Leopoldina
2008	Biochemical Society
2008	World Academy of Art and Science (WAAS)
2004	European Molecular Biology Organization (EMBO)
2003	German Association for Cell Biology (DGZ)
2002	German Society for Biochemistry and Molecular Biology, FEBS and IUBMB
2001	International Union Against Cancer
2001	American Society for Biochemistry and Molecular Biology (ASBMB)
2001	European Life Science Organization (ELSO)
2000	American Association for Cancer Research (AACR)

Awards and Honors

2013	Ernst Jung Prize for Medicine 2013, Jung Foundation for Science and Research, Hamburg, Germany
2013	Gottfried Wilhelm Leibniz Prize of the German Research Foundation, Bonn, Germany
2013	William C. Rose Award 2013, American Association for Molecular Biology and Biochemistry for outstanding achievements, Boston, USA
2010	German Cancer Prize, DKG Berlin, Germany
2010	European Research Council (ERC) Advanced Grant, Brussels, EU
2010	The Order of Duke Branimir for international promotion of Croatia – state honour bestowed by the President of Croatia
2009	Sir Hans Krebs Prize, Medical Faculty Hannover, Hannover, Germany
2008	Award of the International Society of Blood Purification, Brijuni Islands
2008	City of Split Award – Annual Prize for Science, Croatia
2006	AACR Award for Outstanding Achievement in Cancer Research, Washington, USA
2006	Young Cancer Researcher Award, European Association for Cancer Research, Budapest, Hungary
2006	Binder Innovation Prize, German Society for Cell Biology, Braunschweig, Germany
2006	Biomedical Science Prize 2006, Glaxo-Smith-Kline-Foundation, Munich, Germany
2002	Lilla Fernström Award, Lund, Sweden
2000 – 2004	Award of the Strategic Funds for Young Leaders, Sweden
1997 – 2003	Research Award, Boehringer Ingelheim Fonds Germany
1991	D. Perovic Award - Best Medical Graduate (GPA 5,0) at University of Zagreb, Croatia
1991	Rector's Award, University of Zagreb, Croatia
1990	Award for Distinguished Students, University of Zagreb, Croatia

Honorary Lectures

2012	Keynote Lecture, National Congress of Biochemistry and Molecular Biology, Chengdu, China
2012	Keynote Lecture, EMBO Molecular Medicine meeting, Cavtat, Croatia
2011	John Humphrey Lecture, Imperial College London, UK
2011	Keynote Lecture, British Society of Cell Biology, Liverpool, UK
2010	Severo Ochoa Lecture, CBM Madrid, Spain
2009	Keynote Lecture, EMBO meeting on Autophagy, Ascona, Switzerland

Board Member

2012 –	Member of the Board of Reviewing Editors, eLife Journal
2012 –	Editorial Board Member, Developmental Cell
2012 – 2015	Scientific Advisory Board Member, MRC Phoshphorylation and Ubiquitination Unit, Dundee, Scotland
2011 –	Editorial Board Member, Journal of Cell Biology
2011 – 2013	Editorial Board Member, Biological Chemistry
2010	Scientific Advisory Board Member, Ubiquigent, Dundee, Scotland
2010	Scientific Advisory Board Member, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark
2010 – 2012	Advisory Board member, Institute of Enzymology, Hungarian Academy of Sciences, Budapest
2010 – 2014	International Advisory Board member, International Institute of Molecular and Cell Biology, Warsaw, Poland
2009 –	BMC Biology Editorial Board Member, BioMed Central, London, UK
2008 –	Member of the EMBO/EMBL Symposia Committee
2007	Editorial Board member Biochemical Journal
2007	Advisory Editorial Board member EMBO Journal, EMBO Reports
2006	Associate editor, Cancer Research
2006 – 2010	International Advisory Board member, International Institute of Molecular and Cell Biology, Warsaw, Poland
2006	Scientific Advisory Board member of IFOM, Milan
2005 – 2009	Scientific Advisory Board member of Association for International Cancer Research
2005	Highlights Advisor, Nature Reviews Molecular Cell Biology
2003 – 2008	Editorial Board member, Journal of Biological Chemistry
2002 – 2003	Scientific Advisory Board, Betagenon, Stockholm, Sweden

Scientific meetings

2013	Co-organizer EMBO meeting on Ubiquitin and SUMO, Riva del Garde, Italy
2013	Co-organiser Abcam meeting on Ubiquitin and Autophagy, Amsterdam, Netherlands
2012	Organiser, Keystone Symposium “Ubiquitin Signaling”, Whistler, Canada
2012	Organiser, Mosbacher Colloquium “Chemistry and biology of Signal integration”, Mosbach, Germany
2012	Co-organiser, EMBO Practical Course on Ubiquitin and SUMO, Sardinia, Italy
2011	Organiser of the session “Protein synthesis and degradation”, ASBMB Annual Meeting, Washington, USA
2010	Chair, EMBO Conference: “At the joint edge of cellular microbiology & cell biology" – Krakow, Poland
2010	Co-organiser, EMBO Lecture Course Ubiquitin and DNA Damage response, Rovinj, Croatia
2010	Co-Organiser, EMBO Practical Course on Ubiquitin and SUMO, Split, Croatia
2009	Organiser, FEBS Practical Course on Protein Interaction Modules, Split, Croatia
2008	MedILS Summer School: Hot topics in Protein research, Split, Croatia
2008	Co-chair, ELSO Annual meeting, Nice, France
2008	Chair, EMBO Conference: Molecular medicine and cellular signalling, Dubrovnik, Croatia
2008	Co-chair, EMBO Conference: At the joint edge of cellular microbiology and cell biology, Villars-sur-Ollon, Swiss
2006 – 2008	Organiser, EMBO Practical Course on Ubiquitin and SUMO, Split, Croatia
2004	Organiser, FEBS Lecture Course on Cellular Signalling, Dubrovnik, Croatia
2001	Chair, EMBO Lecture Course on Signalling and Development, Split, Croatia
1998 – 2006	Founder and co-organizer, Dubrovnik conferences on Signaling, Dubrovnik/Cavtat, Croatia
1997 – 2012	Mentor for 10 Ph.D. and 9 M.Sc. students
2003 – 2012	Numerous seminars, practicum for medical students in Goethe
2008	MedILS summer school and practical courses, Split, Croatia
2004 -	EMBO and FEBS summer schools and practical courses
2003 – 2004	Seminar courses and computer-based problem solving practicum in Biochemistry at the Goethe University Medical School, Frankfurt, Germany
2000 – 2001	Graduate course in Cellular Signalling - Karolinska Institute, Hudinge, Sweden
2000	Advanced Course in “Physiology: Cellular and Molecular Aspects”, The Wenner-Gren Institute, Stockholm University, Sweden
2000	Graduate Course in Molecular Biology, Split University, Split, Croatia
1999 – 2000	Graduate Course in Cell Signalling, Uppsala University, Uppsala, Sweden
1995 – 1997	Research Instructor, New York University, Medical School, NY, USA

David McEwan

David studied Medical Biochemistry at the University of Glasgow and completed a one-year placement in the protein biochemistry department at GlaxoSmithKline, Harlow, UK.
He graduated in 2003 and started his PhD studies at the Beatson Institute for Cancer Research, Glasgow under the supervision of Prof. Margaret Frame.
This was a collaborative study with Prof. Miles Houslay (University of Glasgow) aimed at investigating the effect of cyclic-AMP on colon cancer survival.
David completed his PhD in October 2007 and started his post-doctoral studies in February 2008 with Prof. Ivan Dikic's lab in Frankfurt, Germany.
David's current research interests are focused on understanding how the process of autophagy is regulated and how specific proteins/organelles are targeted for degradation.

David McEwan
Postdoctoral fellow


Name	David George McEwan


Education

Oct. 2003 – Sept. 2007	Beatson Institute for Cancer Research
	Doctor of Philosophy (PhD) in Biochemistry and Molecular Biology

Title	Cyclic AMP modulation and its Effects on Chemo-resistant Colon Cancer cell Proliferation and Survival.
Supervisors	Prof. Margaret Frame and Prof. Miles Houslay
Aims	Addressing the role of the second messenger cAMP in the regulation of colon cancer proliferation and survival. This work will provide further insights into the compartmentalised signalling pathways that regulate cAMP and its effects on proliferation with a view to developing new therapeutic strategies to combat colon cancer. For a detailed description of my PhD project please see appendix.

October 1998 – June 2003	University of Glasgow
	MSci Medical Biochemistry (with work placement), Upper second class

Final year project	To study the effects of the immunophillin XAP2 on the protein kinase A (PKA) mediated phosphorylation and activity of a phosphodiesterase isoform, PDE4A5, under conditions that maximally activate PKA.

Dissertation	Purine Alkaloids: Importance to plants & their effects on humans.

August 1992 - June 1998	St Andrews Academy, Paisley CSYS Maths, 6 Highers (English B, biology A, chemistry B, maths B, physics B, technological studies B and computing studies B)

Professional experience

October 2001 – September 2002	GlaxoSmithKline, Harlow, Essex

Protein expression and purification group.	During my industrial placement I was an integral part of a team that helped purify proteins that were required for various studies in the target to lead phase of drug development. The placement supplied me with the basic laboratory skills that have provided the foundations from which I have been able to build upon. Techniques employed included ion exchange chromatography, gel filtration and protein refolding to purify proteins to various degrees. LC/MS, peptide mass fingerprinting and N-terminal sequencing were also used to identify and aid the characterisation of purified proteins.

Publications

Novak I*, Kirkin V*, McEwan DG*, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichtert A, Terzic J, Doetsch V, Paul N, Dikic I. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Reports, 2010, in press. (*Equal contributing authors)

Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell. 2009; 34(3):259-69

Kirkin V, Lamark T, Sou YS, Bjorkoy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Overvatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T. A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates. Mol Cell 2009; 33: 505-16.

Sandilands E, Akbarzadeh S, Vecchione A, McEwan DG, Frame MC, Heath JK. Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors. EMBO Rep 2007; 8: 1162-9.

McEwan DG, Brunton VG, Baillie GS, Leslie NR, Houslay MD, Frame MC. Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. Cancer Res 2007; 67: 5248-57.

Bolger GB, Peden AH, Steele MR, MacKenzie C, McEwan DG, Wallace DA, Huston E, Baillie GS, Houslay MD. Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. J Biol Chem 2003; 278: 33351-63.

Tobias Kensche

Tobias Kensche came to Frankfurt to study Biology and he finished his diploma degree in 2006 (equivalent to Masters degree). He studied a diverse range of topics including Anthropology and Cell Biology. Tobias's diploma thesis was conducted under the supervision of Prof. H. D. Osiewacz, where he investigated the molecular mechanisms of aging, and in particular, the role of small mitochondrial HSPs in the fungus Podospora anserina. In 2007 he started his PhD in the lab of Prof. Ivan Dikic at the Institute of Biochemistry II, Frankfurt. Tobias is currently investigating the role of Ubiquitin and Ubiquitin binding domains (UBDs) in inflammatory signaling pathways.

Tobias Kensche
PhD. Student

Name	Tobias Kensche

Educations
2000-2006	Diploma in Biology (Institute of Molecular Biosciences, Prof. H. D. Osiewacz) Johann Wolfgang Goethe-University Frankfurt am Main
Since 2007	Ph.D.-Student at the Institute of Biochemistry II J. W. Goethe University Medical School In Ivan Dikic' group: Molecular signaling.

Philip Wild

Philipp Wild studied Biochemistry at the Eberhard Karls University, Tübingen and obtained his diploma degree in 2007. He did his diploma work under the supervision of Dr. Antonin at the Friedrich Miescher Laboratory of the Max Planck Society investigating the molecular mechanism underlying the nuclear import of Cyclin B1. In 2008 he joined the lab of Prof. Ivan Dikic as a PhD student, studying the role of autophagy receptors in immune signaling.

Philip Wild
PhD. Student

Name	Philip Wild

Educations
2008	PhD student at the Institute of Biochemistry II J. W. Goethe University Medical School Ivan Dikic group: Molecular Signaling
2006 - 2007	Diploma thesis under supervision of Dr. Antonin at the Friedrich Miescher Laboratory in Tübingen. Title of Diploma thesis: "Investigation of the nuclear import mechanism of Cyclin B1".
2003-2004	Academic year at the Max-Planck-Institute of Biochemistry, Martinsried
2001-2006	Study of Biochemistry at the Eberhard Karls University of Tübingen
2000	Abitur at the Hegel-Gymnasium, Stuttgart
1981	born 23.4.1981 in Stuttgart, Germany

Sjoerd van Wijk

Sjoerd van Wijk was born in Rotterdam, the Netherlands where he was trained as research technician.
In 2004, he graduated cum laude from Maastricht University, the Netherlands. After that, he finished his PhD in the lab of Prof. Marc Timmers (Department of Physiological Chemistry, University Medical Centre Utrecht, the Netherlands, working on the genome-wide selectivity of E2 and E3 enzymes in the human ubiquitin system, using a combination of high-throughput yeast two-hybrid screens and homology modeling and molecular dynamics analysis.
From that moment, he started as post-doc in the lab of Ivan Dikic, working on systems biology of ubiquitin signaling using a combination of high-accuracy mass-spectrometry and quantitative single molecule microscopy, in healthy and oncogenic conditions.

Sjoerd van Wijk
Postdoctoral fellow

Name	Sjoerd J. L. van Wijk, PhD
Present	Post-doctoral fellow, Molecular Signaling (Prof. dr. Ivan Dikic), Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany

Education:

2004-2009	PhD, Department of Physiological Chemistry, University Medical Center Utrecht, the Netherlands (advisor: Prof. dr. H. Th. Marc Timmers)
2002-2004	M.Sc. (cum laude) in Biological Health Sciences, Maastricht University, Maastricht, the Netherlands
1996-2000	Biomedical Research technician, Rotterdam University of Applied Sciences, Rotterdam, the Netherlands

Work experience

2000-2002	Research technician, Department of Human Biology, Maastricht University, Maastricht, the Netherlands

Publications

Van Wijk SJL* , Melquiond ASJ*, De Vries SJ, Timmers HThM and Bonvin AMJJ. Dynamic Control of Selectivity in the Ubiquitination Pathway Revealed by an ASP to GLU Substitution in an Intra-molecular Salt-bridge Network. (Plos Comp. Biol., accepted, september 2012) (* equally contributing authors)

Van Wijk SJL, , Fiskin E, Putyrski M, Pampaloni F, Hou J, Wild P, Kensche T, Grecco HE, Bastiaens P, Dikic I. Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. (2012) Mol. Cell. Sep 14;47(5):797-809.

Van Wijk SJL, Bienko M, Dikic I. Role of UbL family modifiers and their binding proteins in cell signaling. (2012) Methods Mol. Biol. 832:163-71.

Van Wijk SJL, Müller S, Dikic I. Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair. (2011) Genes Dev. Sep 1;25(17):1763-9.

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJL, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I. (2011) SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 471(7340):637-41

Van Wijk SJL (2010) Selectivity of E2-E3 interactions in the human ubiquitin system, PhD Thesis, Utrecht University, ISBN 9789088911446

Van Wijk SJL & Timmers HThM (2009) The family of ubiquitin-conjugating enzymes (E2s): deciding between the life and death of proteins. FASEB J. November 25, 2009 as doi:10.1096/fj.09-136259

Van Wijk SJL , De Vries SJ, Kemmeren P, Huang A, Boelens R, Bonvin AMJJ & Timmers HThM (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol. Syst. Biol. 5, 295

Van Wijk SJL & Hageman GJ (2005) Poly(ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Rad. Biol. Med. 39, 81-90

Name

Aliaksandr received his PhD under supervision of Prof. Jonathan C. Howard in the Institute for Genetics in Cologne, Germany, working on mechanisms of innate immunity to the protozoan parasite Toxoplasma gondii.
Soon after that he started postdoctoral training in the Molecular Signalling Group led by Prof. Ivan Dikic.
One of major focuses of research is to advance understanding of selectivity of autophagy process.

Aliaksandr Khaminets
Postdoctoral fellow


Name	Aliaksandr Khaminets

Education

06/2005	Diploma "Biologist-Biotechnologist. Teacher of biology", Belarusian State University, Minsk, Belarus. GPA: 4.8/5.0 (with honor)
05/2010	Ph.D. degree in genetics. Cell Genetics laboratory, Department of Cell Genetics, Institute for Genetics, University of Cologne, Germany, mark: 1.0 (magna cum laude/very good).

Professional experience

03/2003-05/2005	Research work in Molecular Biology laboratory, Microbiology Department, Belarusian State University, Minsk, Belarus. Diploma project: "The distinctive features of pectin substances utilization in Erwinia species kduD mutant strains." Diploma thesis advisor: Dr. Yaugen Uladzislau Miamin.
09/2005-04/2006	Theoretical and practical courses at the Graduate School for Genetics and Functional Genomics, Institute for Genetics, Cologne, Germany
04/2008	Collaboration with Prof. Dr. Simon Gordon, Oxford, United Kingdom. Project: "Investigation of IRG protein association with Candida albicans vacuoles."
04/2006-09/2010	Research work in Cell Genetics laboratory, Department of Cell Genetics, Institute for Genetics, Cologne, Germany. PhD project: "Mechanisms of Cell-autonomous Resistance to Toxoplasma gondii in Mouse and Man." Ph.D. thesis advisor: Prof. Dr. Jonathan C Howard.
09/2010-currently	Postdoctoral research in Molecular Signalling Group of the Institute of Biochemistry II, Medical Faculty of the Goethe University, Frankfurt on Main, Germany. Supervisor: Prof. Dr. Ivan Dikic

Awards

09/2005	Stipend of the Graduate School for Genetics and Functional Genomics, Institute for Genetics, Cologne, Germany.

Publications

Zhao, Y.O., Khaminets, A., Hunn, J.P. and Howard, J.C. (2009). Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunityrelated GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathogens 5, e1000288.

Zhao, Y.O., Rohde, C., Lilue, J.T., Könen-Waisman, S., Khaminets, A., Hunn, J.P. and Howard, J.C. (2009). Toxoplasma gondii and the Immunity-Related GTPase (IRG) resistance system in mice: a review. Mem Inst Oswaldo Cruz 104, 234-240.

Khaminets, A., Hunn, J.P., Könen-Waisman, S., Zhao, Y.O., Preukschat, D., Coers, J., Boyle, J.P., Ong, Y., Boothroyd, J.C., Reichmann, G., Howard, J.C. (2010) Coordinated Loading of IRG Resistance GTPases on to the Toxoplasma gondii Parasitophorous Vacuole. Cellular Microbiology, DOI: 10.1111/j.1462- 5822.2010.01443.x.

Pawlowski N., Khaminets A., Hunn J.P., Papic N., Schmidt A., Lange R., Vopper G., Martens S., Wolf E., Howard J.C. Activation of the immunity- related GTPase Irga6 in resistance to Toxoplasma gondii (in preparation).

Michael Olma

Michael Olma earned his PhD in Zurich, Switzerland, investigating the role of human cullin 4-based E3 ubiquitin ligases on cell cycle regulation in the lab of Prof. Matthias Peter, ETH Zurich, Switzerland. His main interest in the lab of Ivan Dikic is to extend the field of linear ubiquitin chains using mass spectrometry and biochemistry.

Michael Olma
Postdoctoral fellow

Name	Michael Olma

Educations

2011 - Present	Postdoc in Prof. Ivan Dikic's lab, Institute of Biochemistry II, Johann Wolfgang Goethe University, Frankfurt, Germany

2004-2010	Ph. D. and Postdoctoral studies in the lab of Prof. Matthias Peter, ETH Zurich, Switzerland: “Functional analysis of human Cullin 4 E3 Ubiquitin ligases”

1998-2003	Master studies in biochemistry at the Free University Berlin, Germany

Publications

Piwko, W.*, Olma. M.H.*, Held, M., Bianco, J., Pedrioli, P.G., Hofmann, K. Pasero, P., Gerlich, D.W., Peter, M. (* equal contribution); RNAi-based screening identifies the Mms22L- Nfkbil2 complex as a novel regulator of DNA replication in human cells; EMBO Journal, 2010 Dec, 29(24):4210-22

Olma, M.H.*, Roy, M.*, Bihan, T.L., Sumara, I., Maerki, S., Larsen, B., Quadroni, M., Peter, M., Tyers, M., Pintard, L. (* equal contribution); An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases; Journal of cell science, 2009 Apr, 122(7):1035-44

Maerki, S., Olma, M.H., Staubli, T., Steigemann, P., Gerlich, D.W., Quadroni, M., Sumara, I., Peter, M.; The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis; Journal of cell biology, 2009 Dec, 187(6): 791-800

Held, M., Schmitz, M.H., Fischer, B., Walter, T., Neumann, B., Olma, M.H., Peter, M., Ellenberg, J., Gerlich, D.W.; CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging; Nature Methods, 2010 Sep; 7(9): 747-54

Sumara, I., Quadroni, M., Frei, C., Olma, M.H., Sumara, G., Ricci, R., Peter, M.; A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells; Developmental Cell, 2007 Jun, 12(6):887-900

Huber, D., Boyd, D., Xia, Y., Olma, M.H., Gerstein, M., Beckwith, J.; Use of thioredoxin as a reporter to identify a subset of Escherichia coli signal sequences that promote signal recognition article-dependent translocation; Journal of bacteriology, 2005 May, 187(9):2983-91

Jaime Lopez-Mosqueda

Jaime was born and raised in Los Angeles, California. He obtained his Bachelor's degree from the California State University, Northridge. Jaime then ventured to Northern California where he obtained his Ph.D. from the University of California, San Francisco. Under the mentorship of Prof. David Toczyski, Jaime's dissertation focused on how DNA replication is regulated during adverse conditions. He is now an EMBO fellow in the lab of Prof. Ivan Dikic in Frankfurt, Germany. Jaime is currently investigating the role of Wrnip1 and ubiquitin signaling in DNA metabolism.

Jaime Lopez-Mosqueda
Postdoctoral fellow

Name	Jaime Lopez-Mosqueda

Educations

September 2004- March 2011	University of California, San Francisco; San Francisco, California. Ph.D. Biomedical Sciences Graduate Program Thesis Advisor: David P. Toczyski

August 2002- June 2004	San Francisco State University; San Francisco, California M.A. Cell and Molecular Biology (degree not conferred) Thesis Advisor: Frank McCormick

September 1996- May 2002	California State University, Northridge; Northridge, California B.S. Cell and Molecular Biology

Research Experience

2004-2011: Graduate Student; Laboratory of David P. Toczyski; University of California, San Francisco: San Francisco, California.

2002-2004: Student Researcher; Laboratory of Frank McCormick; University of California, San Francisco: San Francisco, California.

Summer 2001: Summer Research Training Program; Laboratory of Thomas Kornberg; University of California, San Francisco: San Francisco, California.

Summer 2000: International Research Training; Laboratory of Marco Antonio Villanueva; Institute of Biotechnology; Universidad Autonoma Nacional de Mexico: Cuernavaca, Morelos, Mexico.

2000-2002: Undergraduate Student Researcher; Laboratory of Randy Cohen; California State University Northridge: Northridge, California.

1998-2000: Undergraduate Student Researcher; Laboratory of Paul Tomasek; California State University Northridge: Northridge, California.

Summer 1998: Summer Internship Program in Biomedical Research; Laboratory of Bruce Paterson; National Institutes of Health, National Cancer Institute: Bethesda, Maryland.

Teaching Experience

2007-2008: Laboratory Instructor; General Biology I and II, Biology Department; University of San Francisco; San Francisco, California.

Summer 2007; Student Advisor; Summer Research Training Program; University of California, San Francisco: San Francisco, California.

Fall 2005; Teaching Assistant for Macromolecules; Biomedical Sciences Graduate Program; University of California, San Francisco: San Francisco, California.

Honors and Fellowships

2011: EMBO Long-term Fellowship

2006: Alliance for Graduate Education and Professoriate (AGEP) Scholar

2005-2008: Ford Foundation Diversity Pre-Doctoral Fellow

2003-2004: NIH RISE Fellow

2002-2003: NIH PREP Fellow

2002: C.S.U.N Heald Graduate Scholar Award

2000-2002: Minority Access to Research Careers Fellow

Summer 2002: UCSF Summer Research Training Program

Summer 2000: Minority International Research Training Program

1998-2002: Minority Biomedical Research Support Fellow

Summer 1998: NIH/NCI Cancer Research Training Program

Summer 1997: Howard Hughes Summer Fellow

Publications

Lopez-Mosqueda J, Maas NL, Jonsson ZO, DeFazio Eli L, Wohlschlegel J, Toczyski DP. Damaged-Induced Phosphorylation of Sld3 is Important to Block Late Origin Firing. Nature. 467 479-483. 2010

Lopez-Mosqueda J, Vidanes GM, Toczyski DP. Cdc5 blocks in vivo Rad53 activity but not in situ activity (ISA). Cell Cycle. 94266-8. 2010

Selected Presentations

Lopez J, Maas NL, DeFazio Eli L, Wohlschlegel J, Toczyski DP. Damaged-dependent Phosphorylation of Sld3 and Dbf4 is Important to Block Late Origin Firing. Eukaryotic DNA Replication and Genome Maintenance. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. September 2009.

Lopez J, Maas NL, Wohlschlegel J, Toczyski, DP. Regulation of DNA Replication in Response to DNA Damage. 9th Annual St. Jude National Graduate Student Symposium, Memphis, Tennessee. April 2009.

Presentations

Khalili C, Lopez J, Hernandez C, Cohen R. Immunohistochemical localization of glutamate receptors in the hippocampus and cerebellum of the spastic Han-Wistar Rat: Evidence of altered expression. Society for Neuroscience 31st Annual Meeting. San Diego, California. November 2001.

Lopez J, Casso D, Kornberg T. Expression and purification of Drosophila Hedgehog from Schneider 2 cells. Society of Advancement for Chicanos and Native Americans in Science (SACNAS) National Conference. Phoenix, Arizona. September 2001.

Jesu K, Lopez J, DeCampo R, Coyle-Thompson C. Analysis of novel disc-large (dlg) allele, misb and dlg heteroallelic phenotypes in Drosophila melanogaster. 39th Annual Drosophila Research Conference. Washington D.C. March 1998.

Veronique Schaeffer

Véronique did her PhD in joint supervision between the University of Basel (Switzerland) and the University of Strasbourg (France) investigating the role of endogenous neurosteroids in the regulation of neurodegenerative processes. Afterwards, Véronique worked in the group of Dr. Goedert (MRC - Laboratory of Molecular Biology, Cambridge, UK) where she has developed and characterized a transgenic mouse model of TDP-43 proteionopathy. She also conducted another project investigating the effect of autophagy stimulation on neurodegeneration in a mouse model of tauopathy. Véronique is now doing a second postdoc in the lab of Prof. Dikic where she intends to investigate further autophagic pathways.

Veronique Schaeffer
Postdoctoral fellow

Name	Véronique Schaeffer

Educations

2004-2007	PhD in Neurosciences in joint-supervision between University of Basel, Switzerland and University of Strasbourg, France.
2002-2004	Master's degree in Neurosciences - University of Strasbourg, France.
1999-2002	Bachelor's degree in Biology - University of Strasbourg, France.

Experience

Dec 2011 - present	Postdoctoral position, Goethe-University Frankfurt am Main, Frankfurt, Germany (Prof. I. Dikic).
Dec 2007 - Nov 2011	Postdoctoral position, Medical Research Council - Laboratory of Molecular Biology, Division of Neurobiology, Cambridge, United Kingdom (Dr M. Goedert).
Sept 2004 - Nov 2007	PhD student, Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, CH-4012, Basel, Switzerland and Equipe Stéroïdes et Système Nociceptif, Institut des Neurosciences Cellulaires et Intégratives, UMR7168/LC2 CNRS-ULP, Strasbourg, France (PD Dr. A. Eckert and Prof. A.G. Mensah-Nyagan).

Publications

Schaeffer V., Meyer L., Patte-Mensah C., Mensah-Nyagan A.G. 2010. Progress in dorsal root ganglion neurosteroidogenic activity: basic evidence and pathophyiological correlation. Progress in Neurobiology, 92(1):22-41.

Schaeffer V., Meyer L., Patte-Mensah C., Eckert A., Mensah-Nyagan A.G. 2010. Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons. Glia, 58(2):169-180.

Patte-Mensah C., Meyer L., Schaeffer V., Mensah-Nyagan A.G. 2010. Selective regulation of 3 alpha-hydroxysteroid oxido-reductase expression in dorsal root ganglion neurons: a possible mechanism to cope with peripheral nerve injury-induced chronic pain. Pain, 150 (3): 522-534.

Mensah-Nyagan A.G., Meyer L., Schaeffer V., Kibaly C., Patte-Mensah C. 2009. Evidence for a key role of steroids in the modulation of pain. Psychoneuroendocrinology, 34(Suppl. 1):S169-S177.

Schaeffer V., Patte-Mensah C., Eckert A., Mensah-Nyagan A.G. 2008. Selective regulation of neurosteroid biosynthesis in human neuroblastoma cells under hydrogen peroxide-induced oxidative stress conditions. Neuroscience, 151(3):758-770.

Schaeffer v., Meyer L., Patte-Mensah C., Eckert A., Mensah-Nyagan A.G. 2008. Dose-dependent and sequence-sensitive effects of amyloid-beta peptide on neurosteroidogenesis in human neuroblastoma cells. Neurochemistry International, 52(6):948-955.

Meyer L., Venard C., Schaeffer V., Patte-Mensah C., Mensah-Nyagan A.G. 2008. The biological activity of 3a-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury. Neurobiology of Disease, 30(1):30-41.

Mensah-Nyagan A.G., Saredi S., Schaeffer V., Kibaly C., Meyer L., Melcangi R.C., Patte-Mensah C. 2008. Assessment of neuroactive steroid formation in diabetic rat spinal cord using High Performance Liquid Chromatography and Continuous Flow Scintillation Detection. Neurochemistry International, 52(4-5):554-559.

Mensah-Nyagan A.G., Kibaly C., Schaeffer V., Venard C., Meyer L, Patte-Mensah C. 2008. Endogenous steroid production in the spinal cord and potential involvement in neuropathic pain modulation. The Journal of Steroid Biochemistry and Molecular Biology. 109(3-5):286-293.

Schaeffer V., Patte-Mensah C., Eckert A. Mensah-Nyagan A.G. 2006. Modulation of neurosteroid production in human neuroblastoma cells by Alzheimer’s disease key proteins. Journal of Neurobiology, 66(8):868-881.

Patte-Mensah C., Kibaly C., Boudard D., Schaeffer V., Béglé A., Saredi S., Meyer L., Mensah-Nyagan A.G. 2006. Neurogenic pain and steroid synthesis in the spinal cord. Journal of Molecular Neuroscience, 28(1): 17-34.

Anja Bremm

Anja studied Biology at the Georg-August University Göttingen and obtained her Ph.D. from Technische Universität München. Her dissertation focused on the crosstalk between the cell adhesion molecule E-cadherin and EGF receptor signaling in gastric cancer. For her post-doctoral studies, Anja moved to Cambridge (UK) where she worked on atypical K11-linked ubiquitin chains in David Komander's group at the MRC Laboratory of Molecular Biology. Anja is now doing a second postdoc in Prof. Dikic's group where she will continue her work on K11-linked polyubiquitin. Her main interest is the characterization of cellular processes regulated by this atypical post-translational modification.

Anja Bremm
postdoctoral fellow

Name	Anja Bremm

Educations

Jan 2005 – Sep 2008	Technische Universität München (Germany), Institute of Pathology; Ph.D. (Dr. rer. nat.)
Oct 1999 – Nov 2004	Georg-August University Göttingen (Germany); Master in Biology (Dipl.-Biol.)
Work experience
Nov 2012 – present	Goethe University Frankfurt (Germany), Institute of Biochemistry II; Postdoc in Ivan Dikic’s group
Oct 2008 – Oct 2012	MRC Laboratory of Molecular Biology, Cambridge (UK); Postdoc in David Komander’s group
Jan 2005 – Sep 2008	Technische Universität München (Germany), Institute of Pathology; Ph.D. student in Birgit Luber’s group
Jan 2004 – Nov 2004	Max-Planck-Institute for Experimental Medicine, Göttingen (Germany); Master student in Florentina Soto’s group

Publications

Bremm A, Komander D. Synthesis and analysis of K11-linked ubiquitin chains. Methods Mol Biol. 2012

Bremm A, Komander D. Emerging roles for Lys11-linked polyubiquitin in cellular regulation. Trends Biochem Sci. 2011

Bremm A, Komander D. A further case of Dop-ing in bacterial pupylation. EMBP Rep. 2010

Bremm A, Freund SM, Komander D. Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010

Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D. Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain. Nat Struct Mol Biol. 2009

Markson G, Kiel C, Hyde R, Brown S, Charalabous P, Bremm A, Semple J, Woodsmith J, Duley S, Salehi- Ashtiani K, Vidal M, Komander D, Serrano L, Lehner P, Sanderson CM. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res. 2009

Bremm A, Walch A, Fuchs M, Mages J, Duyster J, Keller G, Hermannstädter C, Becker KF, Rauser S, Langer R, von Weyhern CH, Höfler H, Luber B. Enhanced activation of epidermal growth factor receptor caused by tumor-derived E-cadherin mutations. Cancer Res. 2008

Doris Popovic

Doris Popovic studied molecular biology at the University of Zagreb, Croatia, at the Faculty of Science. She did her Diploma at the Institute Ruder Boskovic, Zagreb, under the guidance of Dr. Renata Novak investigating the role of protein CTCF in epigenetic regulation of IGF2 and H19 gene imprinting.
Upon graduation she joined Prof. Dikic group at MedILS, Split , Croatia, for practical programm where she was involved in project: Ubiquitin like modifiers in autophagy.
Currently she is doing her PhD in Prof. Dikic lab Frankfurt working on regulation of autophagy by endocytic pathways and other vesicular trafficking events.

Doris Popovic
PhD. Student

Name	Doris Popovic

Educations

2009- present	PhD student at Institute for Biochemistry II, group of Prof. Ivan Dikic
2008-2009	Practical programm at Mediterranean Institute for Life Sciences, Split, Croatia, Tumor Biology Program group of Prof. Ivan Dikic
2008	Diploma thesis: "CTCF protein binding to H19 ICR in Cal27 cells", Supervision: Dr. Renata Novak Laboratory of molecular pathology, Ruder Boskovic Institute, Zagreb, Croatia
2004-2008	Study of Molecular Biology, Faculty of Math and Natural Sciences, University of Zagreb, Croatia
2004	High School Degree, Chatolic Grammar High School "St. Paul", Zenica, BiH

Evgenij Fiškin

Evgenij studied Biochemistry at the Free University Berlin and obtained his diploma degree in 2010. For his diploma thesis he joined the lab of Sven Diederichs at the German Cancer Research Center in Heidelberg to investigate the role of long-non coding RNAs (lincRNAs) in the DNA damage response. To finish his diploma work he worked in the group of Lee Zou at the Harvard Medical School in Boston. He is now a BIF PhD fellow in the lab of Ivan Dikic in Frankfurt, studying ubiquitin signaling.

Evgenij Fiškin
PhD. Student

Name	Evgenij Il´ič Fiškin
Education:

2011-present	PhD student with Prof. Ivan Dikic at the Institute of Biochemistry II, Frankfurt
12.2009 -11.2010	Diploma thesis under supervision of Sven Diederichs and Lee Zou at the Harvard Medical School, Boston: “Functional role of long non-coding RNAs in DNA damage response”
10.2005 - 11.2010	Diploma studies of Biochemistry at the Free University Berlin
06.2005	Abitur at the Walther-Rathenau-Gymnasium Berlin

Honors and Fellowships:

2011-present	Boehringer Ingelheim Fonds PhD Fellow
2005-2010	German National Academic Foundation Fellow

Publication:

Schubert D, Corda M, Lukin O, Brusilowskij B, Fiškin E, Schalley CA (2008). A Topological View of Isomeric Dendrimers. European Journal of Organic Chemistry, 24, 4148-4156

Masuda Sader

Masuda Sader
MTA

Anja Kirchhof

Anja Kirchhof
MTA