Ivan Dikic was born and brought up in Zagreb, Croatia, where he was trained as a medical doctor, he obtained his PhD in molecular biology from the University of Zagreb while working under the supervision of Joseph Schlessinger at New York University Medical Center, USA.
He became a Group Leader at the Ludwig Institute for Cancer Research, Uppsala, Sweden moving to Frankfurt in 2002.
He is currently a Professor and Director of Institute of Biochemistry II at the Goethe University, Frankfurt, Germany and the Director of the Frankfurt Institute for Molecular life Sciences (FMLS).
He also holds a Guest Professorship at the University of Split, Croatia.
Ivan’s scientific interests are focused on how ubiquitin pathways regulate cellular processes, such as receptor-mediated endocytosis, immune responses, DNA repair, proteasomal degradation and more recently on molecular basis of selective autophagy.
Scientific Advisory Board member of Association for International Cancer Research
2006
Scientific Advisory Board member of IFOM, Milan
2006 – 2010
International Advisory Board member, International Institute of Molecular and Cell Biology, Warsaw, Poland
2006
Associate editor, Cancer Research
2007
Advisory Editorial Board member EMBO Journal and EMBO Reports
2007
Editorial Board member Biochemical Journal
2008
EMBO Advanced Training Centre committee member
2009 - 2012
EMBO Publication committee member
2009 - 2012
ERC Life Science panel member
2009
Landon Foundation-AACR INNOVATOR Award Scientific Review
Committee
2009 - Present
Chairman of Scientific Advisory Group, SCILLS (Scottish Institute for Cell Signalling), University Dundee, Dundee, Scotland
Mentor for students and education
Till 2008
Mentor for 8 Ph.D. and 6 M.Sc. students
2008
MedILS summer schools and practical courses
2004-2008
Numerous seminars, practicum for medical students in Goethe University
2003 – 2004
Seminar courses and computer-based problem solving practicum in Biochemistry at the Goethe University Medical School, Frankfurt, Germany
2000 – 2001
Graduate course in Cellular Signalling - Karolinska Institute, Hudinge, Sweden
2000
Advanced Course in "Physiology: Cellular and Molecular Aspects", The Wenner-Gren Institute, Stockholm University, Sweden
2000
Graduate Course in Molecular Biology, Split University, Split Croatia
1999 – 2000
Graduate Course in Cell Signalling, Uppsala University, Uppsala, Sweden
1995 – 1997
Research Instructor, New York University, Medical School, NY, USA
Patent
Use of EGFL7 for modulation of cells. DE 10 2007 019162.8
Fumio Ikeda
Fumiyo Ikeda was born in Japan and spent one's school years in Osaka.
She graduated from Dental School of Osaka University and then started
a PhD course in biochemistry department of Graduate School of Osaka
University.She continued research in the same department as a staff
scientist for 2 years. After that she joined Ivan Dikic's Lab as a
postdoc and is continuing her research to understand regulatory
mechanisms of inflammatory signaling.
Osaka University, Graduate School of Dentistry, Osaka, Japan
Major
Molecular Biology
Degree
Ph. D. (Doctor of Philosophy)
Dissertation
The Role of JNK/c-Jun Signaling in Osteoclast Differentiation
1993-1999
Osaka University, Dental School, Osaka, Japan
Major
Dentistry
Degree
D.D.S. (Doctor of Dental Science)
Experiences
2005-present
Postdoctoral fellow, Goethe-University Frankfurt am Main, Frankfurt, Germany (Prof. I. Dikic)
2003-2005
Staff scientist, Osaka University, Graduate School of Dentistry, Osaka, Japan (Prof. T. Yoneda)
2000-2003
Research assistant, Osaka University, Graduate School of Dentistry, Osaka, Japan (Prof. T. Yoneda)
Fellowships
2008-2010
Japan Society for the Promotion of Science, JSPS Postdoctoral Fellowship for Research Abroad (Japan)
2005-2007
The Alexander von Humboldt Foundation, Research Fellowship (Germany)
2005
The Uehara Memorial Foundation, Research Fellowship for Research Abroad (Japan)
2002-2003
The Iwadare Scholarship Foundation, Research Fellowship for PhD program (Japan)
1999-2003
The Japan Scholarship Foundation, Research Fellowship for PhD program (Japan)
Awards
2003
2 Young Investigator Awards for 2 abstracts (The American Society of Bone and Mineral Research)
Publications
1- Rahighi S*, Ikeda F*, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S#, Dikic I#. Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-kB Activation, Cell, 136(6), 1098-1109, 2009 * These authors contributed equally to this work
2- Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T. Paraspeckle protein p54nrb links Sox9 mediated transcription with RNA processing during chondrogenesis. J Clin Invest 118(9), 3098-3108, 2008
3- Ikeda F, Matsubara T, Tsurukai T, Hata K, Nishimura R, Yoneda T. JNK/c-Jun Signaling Mediates Anti-Apoptotic Effect of RANKL in Osteoclasts. J Bone Miner Res 23(6), 907-914, 2008
4- Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang KT. Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBOJ 27(4), 629–641, 2008
5- Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R. Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene 27(26), 3739-3745, 2008
6- Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dotsch V, Dikic I. Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J 26(14), 3451-3462, 2007
7- Shimoyama A, Wada M, Ikeda F, Hata K, Matsubara T, Nifuji A, Noda M, Amano K, Yamaguchi A, Nishimura R, Yoneda T. Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol Biol Cell 18(7), 2411-2418, 2007
8- Matsubara T, Myoui A, Ikeda F, Hata K, Yoshikawa H, Nishimura R, Yoneda T. Critical role of cortactin in actin ring formation and osteoclastic bone resorption. J Bone Miner Metab 24(5), 368-372, 2006
9- Ikeda F, Nishimura R, Matsubara T, Hata K, Reddy SV, Yoneda T. Activation of NFAT signal in vivo leads to osteopenia associated with increased osteoclastogenesis and bone-resorbing activity. J Immunol 177(4), 2384-2390, 2006
10- Hiraga T, Hata K, Ikeda F, Kitagaki J, Fujimoto-Ouchi K, Tanaka Y, Yoneda T. Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model. Oncol Rep 14(3), 695-699, 2005
11- Hata K, Nishimura R, Ueda M, Ikeda F, Matsubara T, Ichida F, Hisada K, Nokubi T, Yamaguchi A, Yoneda T. A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes. Mol Cell Biol 25(5), 1971-1979, 2005
12- Ikeda F, Nishimura R, Matsubara T, Tanaka S, Inoue J, Reddy SV, Hata K, Yamashita K, Hiraga T, Watanabe T, Kukita T, Yoshioka K, Rao A, Yoneda T. Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest 114(4), 475-484, 2004
13- Ichida F, Nishimura R, Hata K, Matsubara T, Ikeda F, Hisada K, Yatani H, Cao X, Komori T, Yamaguchi A, Yoneda T. Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem 279(32), 34015-34022, 2004
14- Hiraga T, Ueda A, Tamura D, Hata K, Ikeda F, Williams PJ, Yoneda T. Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer. Int J Cancer 106(6), 973-979, 2003
15- Hata K, Nishimura R, Ikeda F, Yamashita K, Matsubara T, Nokubi T, Yoneda T. Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis. Mol Biol Cell 14(2), 545-555, 2003
16- Nishimura R, Hata K, Harris SE, Ikeda F, Yoneda T. Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5. Bone 31(2), 303-312, 2002
Review Articles
Ikeda F, Dikic I. Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep 9(6), 536-542, 2008
Nishimura R, Hata K, Ikeda F, Ichida F, Shimoyama A, Matsubara T, Wada M, Amano K, Yoneda T. Signal transduction and transcriptional regulation during mesenchymal cell differentiation. J Bone Miner Metab 26(3), 203-122, 2008
Terzic J, Marinovic-Terzic I, Ikeda F, Dikic I. Ubiquitin signals in the NF-kappaB pathway. Biochem Soc Trans 35(Pt 5), 942-945, 2007
Ikeda F, Dikic I. CYLD in ubiquitin signaling and tumor pathogenesis. Cell 125(4), 643-645, 2006
Nishimura R, Hata K, Ikeda F, Matsubara T, Yamashita K, Ichida F, Yoneda T. The role of Smads in BMP signaling. Front in Biosci 8, s275-s284, 2003
David McEwan
David studied Medical Biochemistry at the University of Glasgow and completed a one-year placement in the protein biochemistry department at GlaxoSmithKline, Harlow, UK.
He graduated in 2003 and started his PhD studies at the Beatson Institute for Cancer Research, Glasgow under the supervision of Prof. Margaret Frame.
This was a collaborative study with Prof. Miles Houslay (University of Glasgow) aimed at investigating the effect of cyclic-AMP on colon cancer survival.
David completed his PhD in October 2007 and started his post-doctoral studies in February 2008 with Prof. Ivan Dikic's lab in Frankfurt, Germany.
David's current research interests are focused on understanding how the process of autophagy is regulated and how specific proteins/organelles are targeted for degradation.
Doctor of Philosophy (PhD) in Biochemistry and Molecular Biology
Title
Cyclic AMP modulation and its Effects on Chemo-resistant Colon Cancer cell Proliferation and Survival.
Supervisors
Prof. Margaret Frame and Prof. Miles Houslay
Aims
Addressing the role of the second messenger cAMP in the regulation of colon cancer proliferation and survival. This work will provide further insights into the compartmentalised signalling pathways that regulate cAMP and its effects on proliferation with a view to developing new therapeutic strategies to combat colon cancer. For a detailed description of my PhD project please see appendix.
October 1998 – June 2003
University of Glasgow
MSci Medical Biochemistry (with work placement), Upper second class
Final year project
To study the effects of the immunophillin XAP2 on the protein kinase A (PKA) mediated phosphorylation and activity of a phosphodiesterase isoform, PDE4A5, under conditions that maximally activate PKA.
Dissertation
Purine Alkaloids: Importance to plants & their effects on humans.
August 1992 - June 1998
St Andrews Academy, Paisley CSYS Maths, 6 Highers (English B, biology A, chemistry B, maths B, physics B, technological studies B and computing studies B)
Professional experience
October 2001 – September 2002
GlaxoSmithKline, Harlow, Essex
Protein expression and purification group.
During my industrial placement I was an integral part of a team that helped purify proteins that were required for various studies in the target to lead phase of drug development. The placement supplied me with the basic laboratory skills that have provided the foundations from which I have been able to build upon. Techniques employed included ion exchange chromatography, gel filtration and protein refolding to purify proteins to various degrees. LC/MS, peptide mass fingerprinting and N-terminal sequencing were also used to identify and aid the characterisation of purified proteins.
Publications
Novak I*, Kirkin V*, McEwan DG*, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichtert A, Terzic J, Doetsch V, Paul N, Dikic I. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Reports, 2010, in press. (*Equal contributing authors)
Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell. 2009; 34(3):259-69
Kirkin V, Lamark T, Sou YS, Bjorkoy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Overvatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T. A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates. Mol Cell 2009; 33: 505-16.
Sandilands E, Akbarzadeh S, Vecchione A, McEwan DG, Frame MC, Heath JK. Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors. EMBO Rep 2007; 8: 1162-9.
McEwan DG, Brunton VG, Baillie GS, Leslie NR, Houslay MD, Frame MC. Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. Cancer Res 2007; 67: 5248-57.
Bolger GB, Peden AH, Steele MR, MacKenzie C, McEwan DG, Wallace DA, Huston E, Baillie GS, Houslay MD. Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. J Biol Chem 2003; 278: 33351-63.
Tobias Kensche
Tobias Kensche came to Frankfurt to study Biology and he finished his diploma degree in 2006 (equivalent to Masters degree). He studied a diverse range of topics including Anthropology and Cell Biology. Tobias's diploma thesis was conducted under the supervision of Prof. H. D. Osiewacz, where he investigated the molecular mechanisms of aging, and in particular, the role of small mitochondrial HSPs in the fungus Podospora anserina.
In 2007 he started his PhD in the lab of Prof. Ivan Dikic at the Institute of Biochemistry II, Frankfurt. Tobias is currently investigating the role of Ubiquitin and Ubiquitin binding domains (UBDs) in inflammatory signaling pathways.
Diploma in Biology (Institute of Molecular Biosciences, Prof. H. D. Osiewacz) Johann Wolfgang Goethe-University Frankfurt am Main
Since 2007
Ph.D.-Student at the Institute of Biochemistry II J. W. Goethe University Medical School In Ivan Dikic' group: Molecular signaling.
Philip Wild
Philipp Wild studied Biochemistry at the Eberhard Karls University, Tübingen and obtained his diploma degree in 2007. He did his diploma work under the supervision of Dr. Antonin at the Friedrich Miescher Laboratory of the Max Planck Society investigating the molecular mechanism underlying the nuclear import of Cyclin B1. In 2008 he joined the lab of Prof. Ivan Dikic as a PhD student, studying the role of autophagy receptors in immune signaling.
PhD student at the Institute of Biochemistry II J. W. Goethe University Medical School
Ivan Dikic group: Molecular Signaling
2006 - 2007
Diploma thesis under supervision of Dr. Antonin at the Friedrich Miescher Laboratory in Tübingen. Title of Diploma thesis: "Investigation of the nuclear import mechanism of Cyclin B1".
2003-2004
Academic year at the Max-Planck-Institute of Biochemistry, Martinsried
2001-2006
Study of Biochemistry at the Eberhard Karls University of Tübingen
2000
Abitur at the Hegel-Gymnasium, Stuttgart
1981
born 23.4.1981 in Stuttgart, Germany
Sjoerd van Wijk
Sjoerd van Wijk was born in Rotterdam, the Netherlands where he was trained as research technician.
In 2004, he graduated cum laude from Maastricht University, the Netherlands. After that, he finished his PhD in the lab of Prof. Marc Timmers (Department of Physiological Chemistry, University Medical Centre Utrecht, the Netherlands, working on the genome-wide selectivity of E2 and E3 enzymes in the human ubiquitin system, using a combination of high-throughput yeast two-hybrid screens and homology modeling and molecular dynamics analysis.
From that moment, he started as post-doc in the lab of Ivan Dikic, working on systems biology of ubiquitin signaling using a combination of high-accuracy mass-spectrometry and quantitative single molecule microscopy, in healthy and oncogenic conditions.
Post-doctoral fellow, Molecular Signaling (Prof. dr. Ivan Dikic), Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany
Education:
2004-2009
PhD, Department of Physiological Chemistry, University Medical Center Utrecht, the Netherlands
(advisor: Prof. dr. H. Th. Marc Timmers)
2002-2004
M.Sc. (cum laude) in Biological Health Sciences, Maastricht University, Maastricht, the Netherlands
1996-2000
Biomedical Research technician, Rotterdam University of Applied Sciences, Rotterdam, the Netherlands
Work experience
2000-2002
Research technician, Department of Human Biology, Maastricht University, Maastricht, the Netherlands
Publications
Sjoerd J.L. van Wijk & Geja J. Hageman (2005) Poly(ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Rad. Biol. Med. 39, 81-90
Sjoerd J.L. van Wijk , Sjoerd J. de Vries, Patrick Kemmeren, Anding Huang, Rolf Boelens, Alexandre M.J.J. Bonvin & H.Th. Marc Timmers (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol. Syst. Biol. 5, 295
Sjoerd J.L. van Wijk & H.Th. Marc Timmers (2009) The family of ubiquitin-conjugating enzymes(E2s): deciding between the life and death of proteins. FASEB J. November 25, 2009 as doi:10.1096/fj.09-136259
Sjoerd J.L. van Wijk (2010) Selectivity of E2-E3 interactions in the human ubiquitin system, PhD Thesis, Utrecht University, ISBN 9789088911446
Sjoerd J.L. van Wijk*, Adrien S.J. Melquiond*, H.Th. Marc Timmers & Alexandre M.J.J. Bonvin. A butterfly effect in protein-protein interactions: how minimal differences in E2 sequence determine RING E3 interaction selectivity (manuscript in preparation)
* Equally contributing authors
Name
Aliaksandr received his PhD under supervision of Prof. Jonathan C. Howard in the Institute for Genetics in Cologne, Germany, working on mechanisms of innate immunity to the protozoan parasite Toxoplasma gondii.
Soon after that he started postdoctoral training in the Molecular Signalling Group led by Prof. Ivan Dikic.
One of major focuses of research is to advance understanding of selectivity of autophagy process.
Diploma "Biologist-Biotechnologist. Teacher of biology", Belarusian State
University, Minsk, Belarus. GPA: 4.8/5.0 (with honor)
05/2010
Ph.D. degree in genetics. Cell Genetics laboratory, Department of Cell
Genetics, Institute for Genetics, University of Cologne, Germany, mark: 1.0 (magna
cum laude/very good).
Professional experience
03/2003-05/2005
Research work in Molecular Biology laboratory, Microbiology
Department, Belarusian State University, Minsk, Belarus. Diploma project: "The
distinctive features of pectin substances utilization in Erwinia species kduD mutant
strains." Diploma thesis advisor: Dr. Yaugen Uladzislau Miamin.
09/2005-04/2006
Theoretical and practical courses at the Graduate School for
Genetics and Functional Genomics, Institute for Genetics, Cologne, Germany
04/2008
Collaboration with Prof. Dr. Simon Gordon, Oxford, United Kingdom.
Project: "Investigation of IRG protein association with Candida albicans vacuoles."
04/2006-09/2010
Research work in Cell Genetics laboratory, Department of Cell
Genetics, Institute for Genetics, Cologne, Germany. PhD project: "Mechanisms of
Cell-autonomous Resistance to Toxoplasma gondii in Mouse and Man." Ph.D. thesis
advisor: Prof. Dr. Jonathan C Howard.
09/2010-currently
Postdoctoral research in Molecular Signalling Group of the
Institute of Biochemistry II, Medical Faculty of the Goethe University, Frankfurt on
Main, Germany. Supervisor: Prof. Dr. Ivan Dikic
Awards
09/2005
Stipend of the Graduate School for Genetics and Functional Genomics,
Institute for Genetics, Cologne, Germany.
Publications
Zhao, Y.O., Khaminets, A., Hunn, J.P. and Howard, J.C. (2009). Disruption of the
Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunityrelated
GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathogens 5,
e1000288.
Zhao, Y.O., Rohde, C., Lilue, J.T., Könen-Waisman, S., Khaminets, A., Hunn, J.P.
and Howard, J.C. (2009). Toxoplasma gondii and the Immunity-Related GTPase
(IRG) resistance system in mice: a review. Mem Inst Oswaldo Cruz 104, 234-240.
Khaminets, A., Hunn, J.P., Könen-Waisman, S., Zhao, Y.O., Preukschat, D., Coers,
J., Boyle, J.P., Ong, Y., Boothroyd, J.C., Reichmann, G., Howard, J.C. (2010)
Coordinated Loading of IRG Resistance GTPases on to the Toxoplasma gondii
Parasitophorous Vacuole. Cellular Microbiology, DOI: 10.1111/j.1462-
5822.2010.01443.x.
Pawlowski N., Khaminets A., Hunn J.P., Papic N., Schmidt A., Lange R., Vopper G.,
Martens S., Wolf E., Howard J.C. Activation of the immunity- related GTPase Irga6 in
resistance to Toxoplasma gondii (in preparation).
Michael Olma
Michael Olma earned his PhD in Zurich, Switzerland, investigating the role of human cullin 4-based E3 ubiquitin ligases on cell cycle regulation in the lab of Prof. Matthias Peter, ETH Zurich, Switzerland. His main interest in the lab of Ivan Dikic is to extend the field of linear ubiquitin chains using mass spectrometry and biochemistry.
Postdoc in Prof. Ivan Dikic's lab, Institute of Biochemistry II,
Johann Wolfgang Goethe University, Frankfurt, Germany
2004-2010
Ph. D. and Postdoctoral studies in the lab of Prof. Matthias Peter, ETH
Zurich, Switzerland: “Functional analysis of human Cullin 4 E3
Ubiquitin ligases”
1998-2003
Master studies in biochemistry at the Free University Berlin, Germany
Publications
Piwko, W.*, Olma. M.H.*, Held, M., Bianco, J., Pedrioli, P.G., Hofmann, K. Pasero, P., Gerlich, D.W., Peter, M. (* equal contribution); RNAi-based screening identifies the Mms22L-
Nfkbil2 complex as a novel regulator of DNA replication in human cells; EMBO Journal, 2010 Dec, 29(24):4210-22
Olma, M.H.*, Roy, M.*, Bihan, T.L., Sumara, I., Maerki, S., Larsen, B., Quadroni, M., Peter, M., Tyers, M., Pintard, L. (* equal contribution); An interaction network of the mammalian COP9
signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases; Journal of cell science, 2009 Apr, 122(7):1035-44
Maerki, S., Olma, M.H., Staubli, T., Steigemann, P., Gerlich, D.W., Quadroni, M., Sumara, I., Peter, M.; The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis; Journal of cell biology, 2009 Dec, 187(6): 791-800
Held, M., Schmitz, M.H., Fischer, B., Walter, T., Neumann, B., Olma, M.H., Peter, M., Ellenberg, J., Gerlich, D.W.; CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging; Nature Methods, 2010 Sep; 7(9): 747-54
Sumara, I., Quadroni, M., Frei, C., Olma, M.H., Sumara, G., Ricci, R., Peter, M.; A Cul3-based E3
ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion
of cytokinesis in human cells; Developmental Cell, 2007 Jun, 12(6):887-900
Huber, D., Boyd, D., Xia, Y., Olma, M.H., Gerstein, M., Beckwith, J.; Use of thioredoxin as a
reporter to identify a subset of Escherichia coli signal sequences that promote signal recognition article-dependent translocation; Journal of bacteriology, 2005 May, 187(9):2983-91
Jaime Lopez-Mosqueda
Jaime was born and raised in Los Angeles, California. He obtained his Bachelor's degree from the California State University, Northridge. Jaime then ventured to Northern California where he obtained his Ph.D. from the University of California, San Francisco. Under the mentorship of Prof. David Toczyski, Jaime's dissertation focused on how DNA replication is regulated during adverse conditions. He is now an EMBO fellow in the lab of Prof. Ivan Dikic in Frankfurt, Germany. Jaime is currently investigating the role of Wrnip1 and ubiquitin signaling in DNA metabolism.
University of California, San Francisco; San Francisco, California.
Ph.D. Biomedical Sciences Graduate Program
Thesis Advisor: David P. Toczyski
August 2002- June 2004
San Francisco State University; San Francisco, California
M.A. Cell and Molecular Biology (degree not conferred)
Thesis Advisor: Frank McCormick
September 1996- May 2002
California State University, Northridge; Northridge, California
B.S. Cell and Molecular Biology
Research Experience
2004-2011: Graduate Student; Laboratory of David P. Toczyski; University of California, San Francisco: San Francisco, California.
2002-2004: Student Researcher; Laboratory of Frank McCormick; University of California, San Francisco: San Francisco, California.
Summer 2001: Summer Research Training Program; Laboratory of Thomas Kornberg; University of California, San Francisco: San Francisco, California.
Summer 2000: International Research Training; Laboratory of Marco Antonio Villanueva; Institute of Biotechnology; Universidad Autonoma Nacional de Mexico: Cuernavaca, Morelos, Mexico.
2000-2002: Undergraduate Student Researcher; Laboratory of Randy Cohen; California State University Northridge: Northridge, California.
1998-2000: Undergraduate Student Researcher; Laboratory of Paul Tomasek; California State University Northridge: Northridge, California.
Summer 1998: Summer Internship Program in Biomedical Research; Laboratory of Bruce Paterson; National Institutes of Health, National Cancer Institute: Bethesda, Maryland.
Teaching Experience
2007-2008: Laboratory Instructor; General Biology I and II, Biology Department; University of San Francisco; San Francisco, California.
Summer 2007; Student Advisor; Summer Research Training Program; University of California, San Francisco: San Francisco, California.
Fall 2005; Teaching Assistant for Macromolecules; Biomedical Sciences Graduate Program; University of California, San Francisco: San Francisco, California.
Honors and Fellowships
2011: EMBO Long-term Fellowship
2006: Alliance for Graduate Education and Professoriate (AGEP) Scholar
2005-2008: Ford Foundation Diversity Pre-Doctoral Fellow
2003-2004: NIH RISE Fellow
2002-2003: NIH PREP Fellow
2002: C.S.U.N Heald Graduate Scholar Award
2000-2002: Minority Access to Research Careers Fellow
Summer 2002: UCSF Summer Research Training Program
Summer 2000: Minority International Research Training Program
1998-2002: Minority Biomedical Research Support Fellow
Summer 1998: NIH/NCI Cancer Research Training Program
Summer 1997: Howard Hughes Summer Fellow
Publications
Lopez-Mosqueda J, Maas NL, Jonsson ZO, DeFazio Eli L, Wohlschlegel J, Toczyski DP. Damaged-Induced Phosphorylation of Sld3 is Important to Block Late Origin Firing. Nature. 467 479-483. 2010
Lopez-Mosqueda J, Vidanes GM, Toczyski DP. Cdc5 blocks in vivo Rad53 activity but not in situ activity (ISA). Cell Cycle. 94266-8. 2010
Selected Presentations
Lopez J, Maas NL, DeFazio Eli L, Wohlschlegel J, Toczyski DP. Damaged-dependent Phosphorylation of Sld3 and Dbf4 is Important to Block Late Origin Firing. Eukaryotic DNA Replication and Genome Maintenance. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. September 2009.
Lopez J, Maas NL, Wohlschlegel J, Toczyski, DP. Regulation of DNA Replication in Response to DNA Damage. 9th Annual St. Jude National Graduate Student Symposium, Memphis, Tennessee. April 2009.
Presentations
Khalili C, Lopez J, Hernandez C, Cohen R. Immunohistochemical localization of glutamate receptors in the hippocampus and cerebellum of the spastic Han-Wistar Rat: Evidence of altered expression. Society for Neuroscience 31st Annual Meeting. San Diego, California. November 2001.
Lopez J, Casso D, Kornberg T. Expression and purification of Drosophila Hedgehog from Schneider 2 cells. Society of Advancement for Chicanos and Native Americans in Science (SACNAS) National Conference. Phoenix, Arizona. September 2001.
Jesu K, LopezJ, DeCampo R, Coyle-Thompson C. Analysis of novel disc-large (dlg) allele, misb and dlg heteroallelic phenotypes in Drosophila melanogaster. 39th Annual Drosophila Research Conference. Washington D.C. March 1998.
Doris Popovic
Doris Popovic studied molecular biology at the University of Zagreb, Croatia, at the Faculty of Science. She did her Diploma at the Institute Ruder Boskovic, Zagreb, under the guidance of Dr. Renata Novak investigating the role of protein CTCF in epigenetic regulation of IGF2 and H19 gene imprinting.
Upon graduation she joined Prof. Dikic group at MedILS, Split , Croatia, for practical programm where she was involved in project: Ubiquitin like modifiers in autophagy.
Currently she is doing her PhD in Prof. Dikic lab Frankfurt working on regulation of autophagy by endocytic pathways and other vesicular trafficking events.
PhD student at Institute for Biochemistry II, group of Prof. Ivan Dikic
2008-2009
Practical programm at Mediterranean Institute for Life Sciences, Split, Croatia, Tumor Biology Program group of Prof. Ivan Dikic
2008
Diploma thesis: "CTCF protein binding to H19 ICR in Cal27 cells", Supervision: Dr. Renata Novak
Laboratory of molecular pathology, Ruder Boskovic Institute, Zagreb, Croatia
2004-2008
Study of Molecular Biology, Faculty of Math and Natural Sciences, University of Zagreb, Croatia
2004
High School Degree, Chatolic Grammar High School "St. Paul", Zenica, BiH
Alexis Rozenknop
Alexis Rozenknop studied biochemistry at the University of Toulouse, France. To complete his master degree in "Structural Biology and Proteomics", he accomplished a 8 month trainee at Sanofi-Aventis, Frankfurt, Germany, working on "Protein-Ligand interactions by STD-NMR".
Since january 2007, he has started his PhD, "Functionnal and structural studies of Ubiquitin Like Proteins", as a full collaboration between Prof. Dikic and Prof. Doestch at the University of Frankfurt.
In his project, Alexis is interested in structures and dynamics of Ubiquitin Like Proteins involved in autophagy as well as binding studies with different ligands using techniques as NMR or ITC.
PhD in Biochemistry: “Functionnal and Structural Studies on Ubiquitin Like Protein” at University of Frankfurt, Germany
2005-2006:
2nd year Master Program of Structural Biochemistry and Proteomics, at University of Toulouse, France
2004-2005:
1st year Master Program of Biochemistry-Biotechnologiesat University of Toulouse, France
2003-2004:
Bachelor’s degree in Biochemistry at University of Toulouse, France
Publications
Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, Reichtert A, Terzic J, Doetsch V, Paul N, Dikic I. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Reports 2010, 11(1):45-51
Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I. Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J 2007, 26:3451-62
Shabnam Shaid
Shabnam Shaid completed her degree in medicine in 2007 at the Johannes-Gutenberg University of Mainz, Germany.
There she obtained her MD at the Institute of Medical Microbiology and Hygiene under the supervision of Prof. Dr. Sucharit Bhakdi.
She subsequently worked as a doctor in the Department of Haematology and Oncology at the University clinic in Frankfurt am Main with Head Physician Prof. Dr. Serve.
Shabnam was awarded a grant to research the regulation of autophagy in acute myeloid leukemia in the lab of Prof. Ivan Dikic.
Guest scientist (MD) in Prof. Ivan Dikic's lab. Institute of Biochemistry II, Johan Wolfgang Goethe University, Frankfurt am Main, Germany
Since 1. March 2008
Resident Physician ("Assistenzärztin") at the Dept. of Medicine, ematology/Oncology until currently at the University Hospital of the J. W. Goethe- University, Frankfurt am Main, Germany
11. December 2007
Licence to practice medicine ("Approbation als Arzt"), J. Gutenberg-University, Mainz, Germany
27. November 2007
German Medical Exam Step 2 ("Ärztliche Prüfung, 2. Abschnitt"), J. Gutenberg-University, Mainz, Germany
Since 2004
MD thesis: "Activation of the Epidermal Growth Factor Receptor by S. aureus alpha-Toxin"
11. September 2003
German Medical Exam Step 1 ("Ärztliche Prüfung, 1. Abschnitt"), J. Gutenberg-University, Mainz, Germany
1999 – 2001
Biological-Technical Assistant, Naturwissenschaftliches Technikum, Dr. Künkele Landau
