Tripat Kaur Oberoi* Taner Dogan*, Jennifer C.Hocking, Rolf-Peter Scholz, Juliane Mooz, Carrie L Anderson, Christiaan Karreman, Dagmar Meyer zu Heringdorf, Gudula Schmidt, Mika Ruonala, Kazuhiko Namikawa, Gregory S Harms, Alejandro Carpy, Boris Macek, Reinhard W Koester and Krishnaraj Rajalingam (2011)
Inhibitor of Apoptosis proteins regulate the plasticity cell migration by directly targeting Rac1 for degradation
EMBO J. Nov 25. doi: 10.1038/emboj.2011.423. [Epub ahead of print]
Inhibitor of Apoptosis proteins regulate the plasticity cell migration by directly targeting Rac1 for degradation
EMBO J. Nov 25. doi: 10.1038/emboj.2011.423. [Epub ahead of print]
Philipp Wild, Hesso Farhan, David G. McEwan, Sebastian Wagner, Vladimir V. Rogov, Nathan R. Brady, Benjamin Richter, Jelena Korac, Oliver Waidmann, Chunaram Choudhary, Volker Dötsch, Dirk Bumann, and Ivan Dikic (2011)
Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
Science 1205405
Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
Science 1205405
Finkbeiner E, Haindl M, Muller S
The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex
EMBO J. 2011 Mar 16;30(6):1067-78. Epub 2011 Feb 15
The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex
EMBO J. 2011 Mar 16;30(6):1067-78. Epub 2011 Feb 15
Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I. (2011)
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
Nature 471(7340):637-41
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
Nature 471(7340):637-41
Behrends C, Sowa ME, Gygi SP, Harper JW
Network organization of the human autophagy system
Nature. 2010 Jul 1;466(7302):68-76
Network organization of the human autophagy system
Nature. 2010 Jul 1;466(7302):68-76
Fumiyo Ikeda, Nicola Crosetto, Ivan Dikic, 2010
What Determines the Specificity and Outcomes of Ubiquitin Signaling?
Cell. 24 November; 677-681
Conversation with Prof. Ivan Dikic
One Ubiquitin, 1000s of Partners: How Does Ubiquitin Find Its Target inside the Cell?
What Determines the Specificity and Outcomes of Ubiquitin Signaling?
Cell. 24 November; 677-681
Conversation with Prof. Ivan Dikic
One Ubiquitin, 1000s of Partners: How Does Ubiquitin Find Its Target inside the Cell?
To play this interview, you need a flash player for your browser
Lissanu Deribe Y, Wild P, Chandrashaker A, Curak J, Schmidt MH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I. (2009)
"Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6".
Sci Signal. Dec 22; 2(102):ra84
PMID: 20029029
"Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6".
Sci Signal. Dec 22; 2(102):ra84
PMID: 20029029
Hoeller D, Dikic I. (2009)
Targeting the ubiquitin system in cancer therapy.
Nature. Mar 26;458(7237):438-44.
PMID: 19325623
Targeting the ubiquitin system in cancer therapy.
Nature. Mar 26;458(7237):438-44.
PMID: 19325623
Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I. (2009)
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.
Cell. Mar 20;136(6):1098-109.
PMID: 19303852
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.
Cell. Mar 20;136(6):1098-109.
PMID: 19303852
Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T. (2009)
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Mol Cell. Feb 27;33(4):505-16.
PMID: 19250911
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Mol Cell. Feb 27;33(4):505-16.
PMID: 19250911
Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K. (2008)
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Nat Cell Biol. Dec;10(12):1447-5
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Nat Cell Biol. Dec;10(12):1447-5
Beli P, Mascheroni D, Xu D, Innocenti M (2008)
WAVE and Arp2/3 inhibit filopodium formation by entering into a complex with mDia2.
Nat Cell Biol 10:849-57
WAVE and Arp2/3 inhibit filopodium formation by entering into a complex with mDia2.
Nat Cell Biol 10:849-57
Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters K, Finley D, Dikic I (2008)
Proteasome subunit Rpn13 is a novel ubiquitin receptor.
Nature 453 (7194), 481-488
Proteasome subunit Rpn13 is a novel ubiquitin receptor.
Nature 453 (7194), 481-488
Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters K,
Groll M (2008)
Ubiquitin docking at the proteasome via a novel PH domain interaction.
Nature 453 (7194), 548-552
Groll M (2008)
Ubiquitin docking at the proteasome via a novel PH domain interaction.
Nature 453 (7194), 548-552
Zagrovic B, Dikic I (2008)
Childhood of a phoenix: modern biology in Eastern and South-Eastern Europe.
Nat Rev Mol Cell Biol 9:333-36
Childhood of a phoenix: modern biology in Eastern and South-Eastern Europe.
Nat Rev Mol Cell Biol 9:333-36
Ikeda F, Hecker MC, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dotsch V, Dikic I (2007)
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
EMBO J 26:3451-62
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
EMBO J 26:3451-62
Hoeller D, Hecker CM, Wagner S, Rogov V, Dotsch V, Dikic I (2007)
E3-independent monoubiquitination of ubiquitin-binding proteins.
Mol Cell 26:891-8
E3-independent monoubiquitination of ubiquitin-binding proteins.
Mol Cell 26:891-8
Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I (2006)
Regulation of ubiquitin-binding proteins by monoubiquitylation.
Nat Cell Biol 8:163-9
Regulation of ubiquitin-binding proteins by monoubiquitylation.
Nat Cell Biol 8:163-9
Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R (2007)
Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton.
J Cell Sci 120:395-406
Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton.
J Cell Sci 120:395-406
Stasch JP, Schmidt PM, Nedvetsky PI, Nedvetskaya TY, H S AK, Meurer S, Deile M, Taye A, Knorr A, Lapp H, Muller H, Turgay Y, Rothkegel C, Tersteegen A, Kemp-Harper B, Muller-Esterl W, Schmidt HH (2006)
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.
J Clin Invest 116:2552-61
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.
J Clin Invest 116:2552-61
Hoeller D, Hecker CM, Dikic I (2006)
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis.
Nat Rev Cancer 6:776-88
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis.
Nat Rev Cancer 6:776-88
Seet BT, Dikic I, Zhou MM, Pawson T (2006)
Reading protein modifications with interaction domains.
Nat Rev Mol Cell Biol 7:473-83
Reading protein modifications with interaction domains.
Nat Rev Mol Cell Biol 7:473-83
Schilling K, Opitz N, Wiesenthal A, Oess S, Tikkanen R, Müller-Esterl W, Icking A (2006)
Translocation of endothelial NO synthase involves a ternary complex with caveolin-1 and NOSTRIN.
Mol Biol Cell, 17:3870-80
Translocation of endothelial NO synthase involves a ternary complex with caveolin-1 and NOSTRIN.
Mol Biol Cell, 17:3870-80
Stoeckl L, Funk A, Kopitzki A, Brandenburg B, Oess S, Will H, Sirma H, Hildt E (2006)
Identification of a structural motif crucial for infectivity of hepatitis B viruses.
P Natl Acad Sci USA, 103:6730-34
Identification of a structural motif crucial for infectivity of hepatitis B viruses.
P Natl Acad Sci USA, 103:6730-34
Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Pter M, Lehmann AR, Hofmann K, Dikic I (2005)
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Science 310:1821-1824
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Science 310:1821-1824
Jozic D, Cárdenes N, Lissanu-Derbibe Y, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J (2005)
Cbl promotes clustering of endocytic adaptor proteins.
Nat Struct Mol Biol 12:972-979
Cbl promotes clustering of endocytic adaptor proteins.
Nat Struct Mol Biol 12:972-979
Meurer S, Pioch S, Gross S, Müller-Esterl W (2005)
Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclase.
J Biol Chem 280:33149-33156
Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclase.
J Biol Chem 280:33149-33156
Innocenti M, Gerboth S, Rottner K, Carlier MF, Scita G (2005)
Abi 1 regulates the activity of N-WASP and WAVE in distinct actin-based processes.
Nat Cell Biol 7:969-976
Abi 1 regulates the activity of N-WASP and WAVE in distinct actin-based processes.
Nat Cell Biol 7:969-976
Schleicher M, Brundin F, Gross S, Müller-Esterl W, Oess S (2005)
Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.
Mol Cell Biol 25:8251-8258
Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.
Mol Cell Biol 25:8251-8258
Haglund K, di Fiore PP, Dikic I (2003)
Distinct monoubiquitin signals in receptors endocytosis.
Trends Biochem Sci 28:598-603
Distinct monoubiquitin signals in receptors endocytosis.
Trends Biochem Sci 28:598-603
Haglund K, Sigismund S, Polo S, Szymkiewicz I, di Fiore PP, Dikic I (2003)
Multiple mono-ubiquitination of receptor tyrosine kinases is sufficient for their endocytosis and degradation.
Nat Cell Biol 5:461-6
Multiple mono-ubiquitination of receptor tyrosine kinases is sufficient for their endocytosis and degradation.
Nat Cell Biol 5:461-6