Research Groups

 

 

 

 

 

 


 

 

 

 

 

 

 

 

 

 

Top Publications by Members of the Institute

Lissanu Deribe Y, Wild P, Chandrashaker A, Curak J, Schmidt MH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I. (2009)
"Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6".
Sci Signal. Dec 22; 2(102):ra84
PMID: 20029029

 

Hoeller D, Dikic I. (2009)
Targeting the ubiquitin system in cancer therapy.
Nature. Mar 26;458(7237):438-44.
PMID: 19325623

 

Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I. (2009)
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.
Cell. Mar 20;136(6):1098-109.
PMID: 19303852

 

Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T. (2009)
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

Mol Cell. Feb 27;33(4):505-16.
PMID: 19250911

 

Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K. (2008)
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Nat Cell Biol. Dec;10(12):1447-5

 
Beli P, Mascheroni D, Xu D, Innocenti M (2008)
WAVE and Arp2/3 inhibit filopodium formation by entering into a complex with mDia2.
Nat Cell Biol 10:849-57
 
Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters K, Finley D, Dikic I (2008)
Proteasome subunit Rpn13 is a novel ubiquitin receptor.
Nature 453 (7194), 481-488
 
Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters K,
Groll M (2008)
Ubiquitin docking at the proteasome via a novel PH domain interaction.
Nature 453 (7194), 548-552
 
Grabbe C, Dikic I (2008)
Going global on ubiquitin.
Science 322:872-3.
 

Ikeda F, Dikic I (2008)
Atypical ubiquitin chains: new molecular signals.
EMBO Rep 9:536-42

 
Zagrovic B, Dikic I (2008)
Childhood of a phoenix: modern biology in Eastern and South-Eastern Europe.
Nat Rev Mol Cell Biol 9:333-36
 
Ikeda F, Hecker MC, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dotsch V, Dikic I (2007)
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
EMBO J 26:3451-62
 
Hoeller D, Hecker CM, Wagner S, Rogov V, Dotsch V, Dikic I (2007)
E3-independent monoubiquitination of ubiquitin-binding proteins.
Mol Cell 26:891-8
 
Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I (2006)
Regulation of ubiquitin-binding proteins by monoubiquitylation.
Nat Cell Biol 8:163-9
 
Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R (2007)
Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton.
J Cell Sci 120:395-406
 
Stasch JP, Schmidt PM, Nedvetsky PI, Nedvetskaya TY, H S AK, Meurer S, Deile M, Taye A, Knorr A, Lapp H, Muller H, Turgay Y, Rothkegel C, Tersteegen A, Kemp-Harper B, Muller-Esterl W, Schmidt HH (2006)
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.
J Clin Invest 116:2552-61
 
Hoeller D, Hecker CM, Dikic I (2006)
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis.
Nat Rev Cancer 6:776-88
 
Husnjak K, Dikic I (2006)
EGFR trafficking: parkin' in a jam.
Nat Cell Biol 8:787-8
 
Seet BT, Dikic I, Zhou MM, Pawson T (2006)
Reading protein modifications with interaction domains.
Nat Rev Mol Cell Biol 7:473-83
 
Schilling K, Opitz N, Wiesenthal A, Oess S, Tikkanen R, Müller-Esterl W, Icking A (2006)
Translocation of endothelial NO synthase involves a ternary complex with caveolin-1 and NOSTRIN.
Mol Biol Cell, 17:3870-80
 
Ikeda F, Dikic I (2006)
CYLD in ubiquitin signaling and tumor pathogenesis.
Cell 125:643-5
 
Stoeckl L, Funk A, Kopitzki A, Brandenburg B, Oess S, Will H, Sirma H, Hildt E (2006)
Identification of a structural motif crucial for infectivity of hepatitis B viruses.
P Natl Acad Sci USA, 103:6730-34
 
Schmidt MHH, Dikic I (2005)
The Cbl interactome and its functions.
Nat Rev Mol Cell Biol 6:907-19
 
Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Pter M, Lehmann AR, Hofmann K, Dikic I (2005)
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Science 310:1821-1824
 
Jozic D, Cárdenes N, Lissanu-Derbibe Y, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J (2005)
Cbl promotes clustering of endocytic adaptor proteins.
Nat Struct Mol Biol 12:972-979
 
Meurer S, Pioch S, Gross S, Müller-Esterl W (2005)
Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclase.
J Biol Chem 280:33149-33156
 
Innocenti M, Gerboth S, Rottner K, Carlier MF, Scita G (2005)
Abi 1 regulates the activity of N-WASP and WAVE in distinct actin-based processes.
Nat Cell Biol 7:969-976
 
Haglund K, Dikic I (2005)
Ubiquitylation and cell signaling.
EMBO J 24:3353-3359
 
Schleicher M, Brundin F, Gross S, Müller-Esterl W, Oess S (2005)
Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.
Mol Cell Biol 25:8251-8258
 
Marshall C, Müller-Esterl W (2004)
Spotlight on cellular signaling.
Mol Cell 15:849-52
 
Haglund K, di Fiore PP, Dikic I (2003)
Distinct monoubiquitin signals in receptors endocytosis.
Trends Biochem Sci 28:598-603
 
Dikic I, Giordano S (2003)
Negative receptor signalling.
Curr Opin Cell Biol 15:128-35
 
Haglund K, Sigismund S, Polo S, Szymkiewicz I, di Fiore PP, Dikic I (2003)
Multiple mono-ubiquitination of receptor tyrosine kinases is sufficient for their endocytosis and degradation.
Nat Cell Biol 5:461-6