Cardiovascular Signalling Group
Head: Dr. Stefanie Oess
The function of our body is the result of an immensely complex interplay of different organs and tissues, involving the co-ordinated behaviour of a huge number of different cell types. The complexity becomes even more evident when we look at the subcellular level - at mechanism of signal transduction, gene expression or protein synthesis - where eventually the dynamic function of biomolecules is determined by the rules of chemistry and physics.
This is what marks our fascination and motivates our research: to contribute to the understanding of the molecular control of physiological function and to unravel where perturbations of these intricately regulated systems lead to the development of disease.
Currently our research group focuses on the detailed characterisation of novel signal transduction mechanisms controlling development and function both in the cardiovascular system as well as in brain and facial development. We ultimately aim to understand the function of specific genes in physiological and pathophysiological conditions to a molecular detail that allows us to define targets for preventive strategies and therapeutic interventions.
Dr. Stefanie Oess
Stefanie studied pharmaceutical sciences in Heidelberg and London and obtained her approbation in 1995. She received a PhD in biochemistry from the LMU Munich in 1999. Stefanie has joined the laboratory of Werner Müller-Esterl in Frankfurt in 2000 as a Post-Doc and focused her research interests on signal transduction in the cardiovascular system. Since 2009, Stefanie is an independent group leader at the Institute for Biochemistry II and continues to study signal transduction mechanisms in cardiovascular disease and development.
Alexander studied Interdisciplinary Neuroscience at the Goethe University in Frankfurt am Main. In his master thesis he investigated Wnt- and Hh-signaling in vascular differentiation and angiogenesis. Alexander joined the group of Stefanie Oess in 2014 and his PhD project is focused on the role of the F-BAR protein NOSTRIN in development and function of the cardiovascular system.
Dr. Meike Hoffmeister
Meike studied biology in Oldenburg and received a PhD in biology from the University of Düsseldorf in 2004. Meike joined the Institute of Biochemistry II as a postdoctoral fellow in 2005 and focused her research interests on signalling processes in the cardiovascular system. Since 2009, Meike is a staff scientist in the group of Stefanie Oess and studies signal transduction mechanisms in cardiovascular disease and development.