Dr. Yves Matthess
Yves received his diploma in Biology and Computer Science from the Goethe University of Frankfurt. He developed an inducible shRNA system and an shRNA prediction algorithm for RNA interference (RNAi) to uncover the functions of oncogenes. Applying the inducible RNAi system, a transgenic animal model was implemented to demonstrate cancer addiction of Polo-like kinase 1. Working on the cell cycle at the Institute of Gynecology and Obstetrics in Frankfurt he used RNAi screening technology and high-throughput data analysis for improving drug target opportunities for ovarian cancer patients. In 2018 he joined the IBC2 as postdoctoral scientist building up the FCSC platform. Recently he designed an inducible and multiplex-based CRISPR/Cas9 system for conditional gene knockouts.