Welcome to Institute of Biochemistry II Institute of Biochemistry II an environment where scientists are passionate about their research, where creativity and ideas are generators of success and where lab work and education breed new generations of multidisciplinary professionals.
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Upcoming events
Perspectives in Molecular Medicine Lectures |
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8th Jan 2013 Professor Ivan Dikic receives Ernst Jung Prize for medicine |
8th January 2013. The Jung Foundation for Science and Research announced that Frankfurt professor Ivan Dikic will receive the Ernst Jung Prize 2013 for his groundbreaking work in understanding the role of Ubiquitin in cellular signal regulation. The prize is awarded with 150,000 euro and will be presented at a ceremony on 3rd May in Hamburg.
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6th Dec 2012 Leibniz Prize 2013 for Frankfurt professor Ivan Dikic. |
In recognition of his groundbreaking work in decrypting the Ubiquitin code, Ivan Dikic is to receive the Gottfried Wilhelm Leibniz Prize 2013, Germany's most prestigious scientific award. The award is funded and presented by the German Research Foundation (DFG). It is the research prize with the highest endowment worldwide and comes with a grant of 2.5 M Euro.
Press Release
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Ivan Dikic in DFG 
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16th Oct 2012 Dr.Krishnaraj Rajalingam, an Emmy Noether Fellow from IBCII has been selected to be a PLUS3fellow of the Boehringer Ingelheim Foundation. |
BIF will fund his research on Inhibitors of Apoptosis (IAPs) with a generous support of 825000 euros for the next three years.
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1st August 2012 2013 ASBMB William C. Rose Award goes to BMLS Director Ivan Dikic. |
The Award honors the pioneering work of Ivan Dikic in understanding the Ubiquitin code, and his efforts in training and education of young scientists.
Press Release
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18th June 2012 Seeing Ubiquitin chains in cells. |
An international team of scientists led by IBCII director Ivan Dikic developed specific Ubiquitin biosensors for in vivo application. This approach might mark a major technical breakthrough in detection of Ubiquitin signals in living cells. It is published in today's online issue of Molecular Cell.
Link to full article
PDF Link
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10th May 2012 A novel mechanism regulating SUMO-dependent protein networks. |
The covalent attachment of the ubiquitin-like modifier SUMO to proteins serves an important mechanism for the control of protein-protein interactions. This is generally mediated via recognition of a SUMO-conjugate by an interaction partner that contains a specific SUMO interaction module, termed SIM (SUMO interaction motif). A major question is how the dynamics of SUMO/SIM interactions are regulated. Recent work done by Rebecca Ullmann in Stefan Muller's group together with co-workers from the Lombardi Cancer Center in Washington now uncovered an acetyl-dependent switch that determines the selectivity and dynamics of SUMO-SIM interactions (Molecular Cell, online May 10, 2012). In this context they show that acetylation of SUMO within a basic interface prevents binding to SIMs in PML, Daxx, and PIAS. One the other hand, acetyl-SUMO specifically binds to the Bromodomain of the co-activator p300. This acetyl-dependent switch of SUMO-mediated protein interactions attenuates SUMO-regulated gene silencing and affects the assembly of PML nuclear bodies. This work thus unravels a novel interplay of post-translational modifications that expands the regulatory repertoire of SUMO signaling.
Original Article:
Ullmann R, Chien C D, Avantaggiati M L, Muller S (2012) An acetylation switch regulates SUMO-dependent protein interaction networks, Mol Cell, online May 10, 2012, DOI 10.1016/j.molcel.2012.04.006
Read more about SUMO Signaling Group
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23th January 2012 Novel mechanism regulating cell shape and migration unveiled. Cell shape and migration are controlled by RhoGTPases, a family of small GTPases whose activation is controlled by nucleotide binding. Rac1 is an important member of this family and |
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Read the research highlight from Nat. Rev. Mol. Cell Bio.
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Read more about Krishna Rajalingam
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24th October 2011 Interview with Prof. Dr. Dr. Ivan Dikic, director of the Frankfurt Institute of Molecular Life Sciences (FMLS) If you were granted one wish for the advancement of your research projects, what would this be? Well, I've always valued and emphasized a creative atmosphere. It not only means being surrounded by intelligent people, but also having enough time |
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13th September 2011 ERC Starting Grant awarded to Dr. Christian Behrends: The ERC approved funding for his proposal on Xenophagy and bacterial avoidance (XABA). Briefly, microbial pathogens that successfully parasitize eukaryotic cells have evolved to evade autophagic microbial defenses (xenophagy) and subvert the host autophagic responses for their own survival and/or growth. |
Whole story in Press release
More about Christian Behrends
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26th May 2011 New defense mechanism against Salmonella elucidated: infection with Salmonella, epithelial cells can get rid of the unwanted invader by a process called autophagy. In today's issue of the journal Science, an international group of scientists around IBC2 director Ivan Dikic describes how selectivity is achieved in this process. |
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19th April 2011 A new Emmy Noether Fellow at the IBCII: Dr. Christian Behrends received the prestigious Emmy Noether Research Fellowship by the DFG. His independent group will be funded for three years with a perspective two3 years extension. The mammalian |
More about Christian Behrends
Whole story in Press release
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31st March 2011 - A step towards understanding chronic dermatitis: An international team of scientists led by IBCII director Ivan Dikic discovered a novel role for the protein SHARPIN in immune signalling. |
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1st Feb 2011 - IBCII is pleased to announce its new W2: Prof. Stefan Müller is appointed W2 professor in biochemistry at IBCII and will be an independant group leader for SUMO signaling group. More about Stefan Müller |
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1st Nov. 2010 - New group leader Dr. Christian Behrends from Harvard Medical School in Boston will join IBCII as an independant group leader. He will establish the Autophagy signaling group. More about Christian Behrends |